{"created":"2023-07-27T06:52:45.456121+00:00","id":46864,"links":{},"metadata":{"_buckets":{"deposit":"41a6dffb-e492-49c8-ad60-363dad69b637"},"_deposit":{"created_by":18,"id":"46864","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46864"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046864","sets":["2812:2813:2818"]},"author_link":["435","81660"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"塩分摂取が心血管系、副腎におけるアンジオテンシノーゲン(ANG)及びアルドステロン合成酵素遺伝子(CYP11B2)発現に及ぼすエピジェネティクス機構(従来考えられていた遺伝学の外側で働いている仕組みの研究)を解析し高血圧との関連を検討した。\n副腎球状層ではCYP11B2タンパク発現の高値と同遺伝子の低メチル化を呈した。食塩感受性高血圧ラットでは高食塩食により血管におけるCYP11B2遺伝子発現の増加、心筋におけるANGmRNA発現の増加および同遺伝子の低メチル化状態を呈した。食塩摂取量がRAAS遺伝子のメチル化に影響し、ホルモン産生や高血圧及び臓器障害に関与している可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Salt-sensitive hypertension is the most popular disease in Japan. CYP11B2 gene expression was elevated and methylation ratio was decreased in human adrenal glomerulosa. High salt diet increased vascular CYP11B2 mRNA expression and angiotensinogen mRNA levels in the heart in salt-sensitive hypertensive rats. Hypomethylation status of angiotensinogen gene was seen in the heart. High salt diet may influence methylation status of genes of renin-angiotensin-aldosterone system and cause hypertension.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25461244, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「食塩感受性高血圧の成因に関するエピジェネティスク解析」課題番号:25461244\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461244/25461244seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院先端医療開発センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053191","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90242544"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90242544","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461244/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461244/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461244/25461244seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461244/25461244seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-14"}],"displaytype":"detail","filename":"HO-PR-TAKEDA-Y-kaken 2016-5p.pdf","filesize":[{"value":"208.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAKEDA-Y-kaken 2016-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46864/files/HO-PR-TAKEDA-Y-kaken 2016-5p.pdf"},"version_id":"1bd4309d-8a20-44b4-9d72-b8ef8ab4ea46"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"食塩感受性高血圧の成因に関するエピジェネティスク解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食塩感受性高血圧の成因に関するエピジェネティスク解析"},{"subitem_title":"Epigenetics of renin-angiotensin-aldosterone in salt-sensitive hypertension","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-14"},"publish_date":"2019-02-14","publish_status":"0","recid":"46864","relation_version_is_last":true,"title":["食塩感受性高血圧の成因に関するエピジェネティスク解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:49:08.651992+00:00"}