{"created":"2023-07-27T06:52:46.403216+00:00","id":46885,"links":{},"metadata":{"_buckets":{"deposit":"dd4e7783-4b6b-43ed-92b6-fcf8d757094c"},"_deposit":{"created_by":18,"id":"46885","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46885"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046885","sets":["2812:2813:2840"]},"author_link":["81641","81640"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3p.","bibliographicVolumeNumber":"1992-1993","bibliographic_titles":[{"bibliographic_title":"平成5(1993)年度 科学研究費補助金 一般研究(B) 研究成果報告書"},{"bibliographic_title":"1993 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1.2-Hydroxy-1'-methylzeatin(I)の両対掌体を合成するために,D-及びL-alanineから出発して[R-(E)]-及び[S-(E)]-4-amino-2-methyl-2-penten-1-ol ethanedioate[(R)-II及び(S)-II]を合成した.Et_3Nの存在下2-hydroxy-6-methylthiopurineに(R)-II及び(S)-IIをそれぞれ反応させることで(1'R)-I及び(1'S)-Iが好収率で得られた.各種スペクトルの比較から,緑藻から単離された新規サイトカイニンはIの構造を有することが判明し,また,サイトカイニン活性の比較によって,天然品は(1'R)-Iの絶対構造を有することが推定された.\n2.D-及びL-alanineから[R-(Z)]-及び[S-(Z)]-4-amino-2-methyl-2-penten-1-ol ethanedioate[(R)-III及び(S)-III]を合成し,これらと6-chloropurineあるいはその9-ribosyl体と反応させることで,(1'R)-及び(1'S)-1'-methyl-cis-zeatin[(1'R)-IV及び(1'S)-IV]あるいはそれらの9-ribosyl体[(1\"R)-V及び(1\"S)-V]を合成した.\n3.上記合成法に類似した反応経路で,(1'R)-及び(1'S)-N^6-(1,3-dimethyl-2-butenyl)adenine[(1'R)-VI及び(1'S)-VI]やそれらの9-ribosyl体[(1\"R)-VII及び(1\"S)-VII]を合成した.\n4.cis-Zeatinの新規合成法として,「α-アミノアルデヒド/オレフィン化法」を開発した.この応用で9-(2-deoxy-β-D-ribofuranosyl)-cis-zeatin(VIII)を合成することができた.\n5.タバコ・カルス検定法及びレタス種子発芽検定法によって,上記の天然型関連新規サイトカイニン類[(1'R)-I,(1'S)-I,(1'R)-IV,(1'S)-IV,(1\"R)-V,(1\"S)-V,(1'R)-VI,(1'S)-VI,(1\"R)-VII,(1\"S)-VII,及びVIII]や既知の天然サイトカイニン類のサイトカイニン活性を調べ,構造-活性相関について興味ある知見を得ることができた.","subitem_description_type":"Abstract"},{"subitem_description":"1. The first chiral synthesis of 2-hydroxy-1'-methyl-trans-zeatin (1)has been accomplished. The systhesis started from D-or L-alanine and proceeded through an alpha-amino aldehyde/olefination route to give[R-(E)]-or[S-(E)]-4-amino-2-methyl-2-penten-1-ol ethanedioate [(R)-2 or (S)-2]. Condensations of 2-hydroxy-6methylthiopurine with (R)-2 and (S)-2 furnishied (1'R)-1 and (1'S)-1, respectively. As a result or this synthesis, the gross structure of a marine green alga cytokinin was established to be 1.\n2. In a similar manner, [R-(Z)]-and [S-(Z)]-4-amino-2-methyl-2-penten-1-ol ethanedioates [(R)-3 and (S)-3] were prepared from D- and L-alanine, respectively. Condensations of (R)-3 and (S)-3 with 6-chloropurine or its 9-riboside gave (1'R)-and (1'S)-1'-methyl-cis-zeatins [(1'R)-4 and (1'S)-4] or their 9-ribosides [(1\"R)-5 and (1\"S)-5].\n3. Both enantiomers [(1'R)-6 and (1'S)-6] of N^6-(1,3-dimethyl-2-butenyl)adenine (6) and their 9-ribosides [(1\"R)-7 and (1\"S)-7] were synthesized via analogous routes.\n4. A novel synthesis of cis-zeatin was achieved through an alpha-amino aldehyde/olefination route, which was also applied successfully to the synthesis of 9-(2-deoxy-beta-D-ribofuranosyl)-cis-zeatin(8).\n5. The above 1'-or 1\"-methylated derivatives [(1'R)-1, (1'S)-1, (1'R)-4, (1'S)-4, (1\"R)-5, (1\"S)-5, (1'R)-6, (1'S)-6, (1\"R)-7. (1\"S)-7. amd 8] of the zeatin and IPA families were tested for cytokinin activity in the tobacco callus and the lettuce seed germination bioassays to discuss their structure-activity relationships.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:04453152, 研究期間(年度):1992-1993","subitem_description_type":"Other"},{"subitem_description":"出典：「天然型関連新規サイトカイニン類の合成と植物ホルモン作用」研究成果報告書　課題番号04453152\n(KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053212","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学薬学部"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20019649"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20019649","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04453152/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04453152/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-04453152/044531521993kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-04453152/044531521993kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-14"}],"displaytype":"detail","filename":"PH-PR-FUJII-T-kaken 1994-3p.pdf","filesize":[{"value":"41.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-FUJII-T-kaken 1994-3p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46885/files/PH-PR-FUJII-T-kaken 1994-3p.pdf"},"version_id":"51766cd2-1083-4346-8e80-c2ae2df43812"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"天然型関連新規サイトカイニン類の合成と植物ホルモン作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"天然型関連新規サイトカイニン類の合成と植物ホルモン作用"},{"subitem_title":"Syntheses and Cytokinin Activities of the 1'-or 1\"-Methyl Derivatives in the Zeatin and IPA Families","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2840"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-14"},"publish_date":"2019-02-14","publish_status":"0","recid":"46885","relation_version_is_last":true,"title":["天然型関連新規サイトカイニン類の合成と植物ホルモン作用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:53:09.968805+00:00"}