{"created":"2023-07-27T06:52:46.811901+00:00","id":46896,"links":{},"metadata":{"_buckets":{"deposit":"0ece5dd2-c8e6-431f-b138-3ec4b60e6305"},"_deposit":{"created_by":18,"id":"46896","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46896"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046896","sets":["2812:2813:2831"]},"author_link":["81699"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"115p.","bibliographicVolumeNumber":"2001-2002","bibliographic_titles":[{"bibliographic_title":"平成14(2002)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2002 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では,生体吸収性材料による機能的連続体の応用として,薬物送達システム(Drug Delivery System : DDS)を考えた.DDSでは副作用低減の観点から薬物を作用部位に安全かつ効果的に導くことが要求されており,薬物を封入したカプセルでこれを実現する場合,カプセルの分解速度を制御する必要がある.しかし,カプセルのサイズだけで任意の分解特性を得ることは困難である.そこで,本研究ではDDSのカプセルを生体吸収性材料による機能的連続体と考えて形状を設計し,さらにはこれに予め残留応力を与えることで,分解速度や薬物放出時の挙動が調整できるものと考えた.この可能性を確認するため,生体吸収性材料であるポリL乳酸(PLLA)を用いて二次元的な機能的連続体を作製し,これに残留応力が作用するような加工を施した上で,ギ酸を生体内の環境と見たてて分解実験を行い,残留応力が分解時の挙動に及ぼす影響について検討した.具体的には,二次元の機能的連続体として部分によって厚さの異なる不等厚リングをPLLAで作製し,その一部を切り取ってできる断面を改めて接合して不等厚リングの全域にわたり残留応力を発生させる.リングの切り取る部分の大きさを変えることにより発生する残留応力も変化することができるが,材料力学における曲がりばりの理論を用いて,リングの切取り角と最大残留応力の関係を明らかにした.残留応力を作用させた不等厚リングと,そうでないものとでリングが破断するまでの分解の様子を比較した結果,残留応力を有するものの方が著しく分解速度が速く,破断時のリングの開き量もやや大きいという結果が得られた.これにより,生体吸収性材料で不等厚の連続体を作製し,厚さ分布と残留応力の大きさを変えることで,破断に至るまでの分解時間制御が可能で,DDSへの応用における有効性が明らかとなった.","subitem_description_type":"Abstract"},{"subitem_description":"In this study, functional continua made of bio-absorbable material were applied to drug delivery system (DDS). It is necessary to control of absorption time of drug capsule made of bio-absorbable material in drug delivery system, in order to release the drug concentrated at an affected part. It is difficult to control absorption of the drug capsule only by changing size of the capsule. Shape of DDS capsule was designed by considering as a functional continuum made of bio-absorbable material. Drug capsule with non-uniform thickness is useful to control the absorption time because capsule break and drug release occur at a thinnest part of the capsule. Mechanical stress occurred in bio-absorbable material also affect to its absorption ratio, so it is possible to control the absorption time by varying residual stress value if residual stress is given for the drug capsule of DDS. We investigated effect of the non-uniform shape and residual stress to the absorption time in two-dimensional ring made of bio-absorbable material. A Two-dimensional ring with non-uniform thickness was made of PLLA. A part of the ring was cut off and adhere the cutting face again to generate residual stress along the ring. Residual stress depends on cut off length of the ring, and it was determined by curved beam theory. Absorption examination of the ring was carried out in HCOOH solution for the case with and without residual stress. From the results, absorption time of the ring with residual stress was shorter than the case with no residual stress. It was established absorption time of drug capsule in DDS was controllable by capsule shape with non-uniform thickness and residual stress. The method proposed in this study is applicable to design the drug capsule of DDS in case of necessity of precise absorption time control.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:13650079, 研究期間(年度):2001-2002","subitem_description_type":"Other"},{"subitem_description":"出典：「生体吸収性材料による機能的連続体の開発とその医療への応用」研究成果報告書　課題番号13650079\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053223","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学新学術創成研究機構"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20205769"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20205769","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13650079/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13650079/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-13650079/136500792002kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-13650079/136500792002kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-22"}],"displaytype":"detail","filename":"TE-PR-SAKATOMO-J-kaken 2003-115p.pdf","filesize":[{"value":"25.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"TE-PR-SAKATOMO-J-kaken 2003-115p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46896/files/TE-PR-SAKATOMO-J-kaken 2003-115p.pdf"},"version_id":"920014a3-2404-40ef-939c-3c2eff7f27c3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"生体吸収性材料による機能的連続体の開発とその医療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生体吸収性材料による機能的連続体の開発とその医療への応用"},{"subitem_title":"Development of Functional Continua Made of Bio-absorbable Material and Its Application for Medical Technology","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2831"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-22"},"publish_date":"2019-02-22","publish_status":"0","recid":"46896","relation_version_is_last":true,"title":["生体吸収性材料による機能的連続体の開発とその医療への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:40:49.477121+00:00"}