| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-04-01 |
| タイトル |
|
|
タイトル |
Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00053791 |
|
ID登録タイプ |
JaLC |
| 著者 |
Wakabayashi, Yusuke
Oka, Rie
Nakaya, Masako
Karashima, Shigehiro
Kometani, Mitsuhiro
Sakurai, Masaru
Yoshimura, Kenichi
Yoneda, Takashi
|
| 著者別表示 |
大家, 理恵
唐島, 成宙
米谷, 充弘
櫻井, 勝
吉村, 健一
米田, 隆
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学附属病院代謝内科 |
| 書誌情報 |
Journal of Diabetes Research
巻 2018,
p. 1567683-7 pages,
発行日 2018-10-22
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2314-6745 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
|
|
関連識別子 |
10.1155/2018/1567683 |
| 出版者 |
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出版者 |
Hindawi Publishing Corporation |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Objective. Individuals with multiple metabolic risk factors often experience concomitant sleep-disordered breathing (SDB). We aimed to determine the associations of SDB with individual components of metabolic syndrome independent of obesity. Methods. A cross-sectional study was conducted in 1137 employees aged 30–64 years. Apnea-hypopnea index (AHI) was assessed using a portable monitor for obstructive sleep apnea by admission. Of these, 451 participants took an oral glucose tolerance test to assess homeostatic model assessment of insulin resistance (HOMA-IR) and Matsuda insulin sensitivity index (ISI). Results. The odds ratio (OR) of the highest category of the AHI (≥15 episodes per hour) compared to the lowest one (<5 episodes per hour) was significantly elevated for hypertension, for hypertriglyceridemia, and for low HDL-cholesterolemia when adjusted for age, sex, and alcohol and smoking status (). After further adjustment for body mass index (BMI) or waist circumference, the associations for hypertension still remained statistically significant () while those for hypertriglyceridemia and low HDL-cholesterolemia were no longer significant. The association between higher insulin resistance as assessed by HOMA-IR and Matsuda ISI and higher categories of the AHI was also lost after adjustment for BMI. Conclusion. Obesity was a strong confounding factor in the association between SDB and most metabolic risk factors including insulin resistance, except for hypertension. Further longitudinal study is needed to examine the temporal or causal relationships between SDB and metabolic risk factors. This trial is registered with UMIN-CTR UMIN000028067. |
| 権利 |
|
|
権利情報 |
Copyright © 2018 Yusuke Wakabayashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
|
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|
識別子タイプ |
URI |
|
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関連識別子 |
https://www.hindawi.com/journals/jdr/2018/1567683/ |
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関連名称 |
https://www.hindawi.com/journals/jdr/2018/1567683/ |
| 関連URI |
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|
識別子タイプ |
URI |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/30426019 |
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|
関連名称 |
https://www.ncbi.nlm.nih.gov/pubmed/30426019 |
HO-PR-OKA-R-1567683.pdf (806.1 kB)
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