{"created":"2023-07-27T06:53:08.816647+00:00","id":47466,"links":{},"metadata":{"_buckets":{"deposit":"933a6a02-2cf3-4eff-9eb2-39a30f4b33b1"},"_deposit":{"created_by":18,"id":"47466","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47466"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047466","sets":["1761:1762:1763"]},"author_link":["435","533","84108","75030","84101","69427","80729","84098","84106","22197","84109","81660","84107","21527","22200","2716"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9 pages","bibliographicPageStart":"5107589","bibliographicVolumeNumber":"2018","bibliographic_titles":[{"bibliographic_title":"Journal of Diabetes Research"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"青野, 大輔"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大家, 理恵"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"米谷, 充弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"武田, 仁裕"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"唐島, 成宙"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"吉村, 健一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"武田, 仁勇"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"米田, 隆"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim. To characterize subjects with a nonpositive insulinogenic index and longitudinally observe changes in their glucose tolerance. Subjects and Methods. A historical cohort study was conducted using data from the medical checkups of public school workers. Indices of insulin secretion and insulin sensitivity derived from oral glucose tolerance test (OGTT) and the incidences of diabetes and impaired glucose tolerance (IGT) were compared among subgroups of subjects with different insulinogenic index (change in insulin/change in glucose over the first 30 min on the OGTT). Results. Of the 1464 nondiabetic subjects at baseline, 72 (4.9%) subjects had a nonpositive insulinogenic index: 42 of those subjects had a nonpositive glucose response (ΔGlu0–30 ≤ 0) and 30 had a nonpositive insulin response (ΔIns0–30 ≤ 0). Compared with subjects who had normal glucose tolerance (NGT) with insulinogenic index ≥ 0.4, subjects with a nonpositive glucose response had a higher first-phase Stumvoll and lower incidences of diabetes and IGT based on a log-rank test (), whereas subjects with a nonpositive insulin response had lower indices of insulin secretion and a higher incidence of diabetes (). Conclusions. These results demonstrate that in the first 30 min on the OGTT, subjects with a nonpositive insulinogenic index due to a nonpositive glucose response (ΔGlu0–30 ≤ 0) had a lower risk for future diabetes and that subjects with nonpositive insulin response (ΔIns0–30 ≤ 0) had a higher risk for future one.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院代謝内科","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053792","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi Publishing Corporation"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1155/2018/5107589","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.hindawi.com/journals/jdr/2018/5107589/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.hindawi.com/journals/jdr/2018/5107589/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.ncbi.nlm.nih.gov/pubmed/29765987"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pubmed/29765987","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2018 Daisuke Aono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2314-6745","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Aono, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oka, Rie"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kometani, Mitsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeda, Yoshimichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Karashima, Shigehiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoshimura, Kenichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Takeda, Yoshiyu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoneda, Takashi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-01"}],"displaytype":"detail","filename":"HO-PR-OKA-R-5107589.pdf","filesize":[{"value":"815.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-OKA-R-5107589.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47466/files/HO-PR-OKA-R-5107589.pdf"},"version_id":"a9510109-c292-4989-9998-9b44be020e2c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index"}]},"item_type_id":"4","owner":"18","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-01"},"publish_date":"2019-04-01","publish_status":"0","recid":"47466","relation_version_is_last":true,"title":["Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T16:34:01.235417+00:00"}