@article{oai:kanazawa-u.repo.nii.ac.jp:00047489,
 author = {近藤, 悟 and 脇坂, 尚宏 and 辻, 亮 and 遠藤, 一平 and 室野, 重之 and 喜多村, 晃一 and 村松, 正道 and 吉崎, 智一 and Nakanishi, Yosuke and Kondo, Satoru and Wakisaka, Naohiro and Tsuji, Akira and Endo, Kazuhira and Murono, Shigeyuki and Ito, Makoto and Kitamura, Kouichi and Muramatsu, Masamichi and Yoshizaki, Tomokazu},
 issue = {4},
 journal = {PLoS ONE},
 month = {Apr},
 note = {Purpose:In humans, activation-induced cytidine deaminase (AID) expression results due to inflammation and this deaminase activity is also involved in carcinogenesis. The aim of this study is to investigate the correlation between AID expression and the clinical classification of oral cancer tissues.Experimental Design:The current study investigated the correlation between AID expression and the clinical classification of oral cancer tissues from 27 patients who underwent surgical resection using immunohistochemistry. Specific AID expression and its induction by cytokine stimulation were investigated in cultured HSC oral cancer cell lines by reverse transcriptase PCR.Results:AID expression was detected in 10 of 27 specimens (37.0%). AID expression was more frequently detected in early-stage cancer, especially in early stage T, than in late-stage cancer (T1/T2 vs. T3/4; P = 0.0493, N0 vs. N1/2/3; P = 0.0793). HSC-2, a nonmetastatic oral cancer cell line, abundantly expressed endogenous AID, whereas no such expression was observed in HSC-3, a metastatic oral cancer cell line. Moreover, AID expression was substantially induced in HSC-2 cells by stimulation of an inflammation-related cytokine, TNF-α.Conclusions:Aberrant AID expression in the oral epithelium would contribute to the initiation of oral squamous cell carcinoma. Avoiding persistent AID inducible condition such as frequent cleaning of oral cavity would play an important role for the prevention of developing oral cancer. © 2013 Nakanishi et al., 金沢大学医薬保健研究域医学系},
 title = {Role of Activation-Induced Cytidine Deaminase in the Development of Oral Squamous Cell Carcinoma},
 volume = {8},
 year = {2013}
}