| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-04-05 |
| タイトル |
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タイトル |
Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00053819 |
|
ID登録タイプ |
JaLC |
| 著者 |
Seishima, Noriko
Kondo, Satoru
Wakaea, Kousho
Wakisaka, Naohiro
Kobayashi, Eiji
Kano, Makoto
Moriyama-Kita, Makiko
Nakanishi, Yosuke
Endo, Kazuhira
Imoto, Tomoko
Ishikawa, Kazuya
Sugimoto, Hisashi
Hatano, Miyako
Ueno, Takayoshi
Koura, Miki
Kitamura, Kouichi
Muramatsu, Masamichi
Yoshizaki, Tomokazu
|
| 著者別表示 |
近藤, 悟
脇坂, 尚宏
喜多, 万紀子
遠藤, 一平
波多野, 都
小浦, 美樹
喜多村, 晃一
村松, 正道
吉崎, 智一
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
Scientific Reports
en : 8
巻 1,
p. 18732,
発行日 2018-02
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2045-2322 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-017-18732-w |
| 出版者 |
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出版者 |
Springer Nature |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Activation-induced cytidine deaminase (AID) and apolipoprotein B mRNA-editing catalytic polypeptide 3 (A3) family are cytidine deaminases that play critical roles in B-cell maturation, antiviral immunity and carcinogenesis. Adenoids and palatine tonsils are secondary lymphoid immune organs, in which AID and A3s are thought to have several physiological or pathological roles. However, the expression of AID or A3s in these organs has not been investigated. Therefore, we investigated the expression profiles of AID and A3s, using 67 samples of adenoids and palatine tonsils from patients, with reverse transcription quantitative polymerase chain reaction (RT-qPCR) and immunohistochemical analyses. AID and A3s expression levels in the adenoids and the palatine tonsils of the same individual significantly correlated with each other. Of note, AID expression level in the adenoids negatively correlated with the age (r = −0.373, P = 0.003). The younger group with adenoid vegetation and tonsillar hypertrophy showed more abundant AID expression than the older group with recurrent tonsillitis and peritonsillar abscesses (P = 0.026). Moreover, immunohistochemical analysis revealed the distribution of AID and A3s in the epithelial cells as well as germinal centres. The localisation of AID expression and its relation to age may contribute to adenoid vegetation and inflammation. |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Ministry of Education, Culture, Sports, Science and Technology B23390396,A24689064 |
| 権利 |
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|
権利情報 |
Copyright © 2018 The Author(s). |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.nature.com/articles/s41598-017-18732-w |
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関連名称 |
https://www.nature.com/articles/s41598-017-18732-w |
ME-PR-KITAMURA-K-18732-w.pdf (2.7 MB)
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