@article{oai:kanazawa-u.repo.nii.ac.jp:00047493,
 author = {近藤, 悟 and 脇坂, 尚宏 and 喜多, 万紀子 and 遠藤, 一平 and 波多野, 都 and 小浦, 美樹 and 喜多村, 晃一 and 村松, 正道 and 吉崎, 智一 and Seishima, Noriko and Kondo, Satoru and Wakaea, Kousho and Wakisaka, Naohiro and Kobayashi, Eiji and Kano, Makoto and Moriyama-Kita, Makiko and Nakanishi, Yosuke and Endo, Kazuhira and Imoto, Tomoko and Ishikawa, Kazuya and Sugimoto, Hisashi and Hatano, Miyako and Ueno, Takayoshi and Koura, Miki and Kitamura, Kouichi and Muramatsu, Masamichi and Yoshizaki, Tomokazu},
 journal = {Scientific Reports, 8},
 month = {Feb},
 note = {Activation-induced cytidine deaminase (AID) and apolipoprotein B mRNA-editing catalytic polypeptide 3 (A3) family are cytidine deaminases that play critical roles in B-cell maturation, antiviral immunity and carcinogenesis. Adenoids and palatine tonsils are secondary lymphoid immune organs, in which AID and A3s are thought to have several physiological or pathological roles. However, the expression of AID or A3s in these organs has not been investigated. Therefore, we investigated the expression profiles of AID and A3s, using 67 samples of adenoids and palatine tonsils from patients, with reverse transcription quantitative polymerase chain reaction (RT-qPCR) and immunohistochemical analyses. AID and A3s expression levels in the adenoids and the palatine tonsils of the same individual significantly correlated with each other. Of note, AID expression level in the adenoids negatively correlated with the age (r = −0.373, P = 0.003). The younger group with adenoid vegetation and tonsillar hypertrophy showed more abundant AID expression than the older group with recurrent tonsillitis and peritonsillar abscesses (P = 0.026). Moreover, immunohistochemical analysis revealed the distribution of AID and A3s in the epithelial cells as well as germinal centres. The localisation of AID expression and its relation to age may contribute to adenoid vegetation and inflammation., Ministry of Education, Culture, Sports, Science and Technology B23390396,A24689064, 金沢大学医薬保健研究域医学系},
 title = {Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils},
 volume = {1},
 year = {2018}
}