{"created":"2023-07-27T06:53:09.714394+00:00","id":47493,"links":{},"metadata":{"_buckets":{"deposit":"c02a7900-2745-4891-95c9-4d330520cf7c"},"_deposit":{"created_by":18,"id":"47493","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47493"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047493","sets":["1132:1133:1134"]},"author_link":["2011","21449","84348","84350","20177","23230","84208","79","84222","84343","23948","1289","84239","22167","23229","2081","84310","73848","2343","449","23231","45565","2411","84339","22715","84209","21455"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"18732","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"},{"bibliographic_title":"8","bibliographic_titleLang":"en"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"近藤, 悟"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"脇坂, 尚宏"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"喜多, 万紀子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"遠藤, 一平"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"波多野, 都"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小浦, 美樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"喜多村, 晃一"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"村松, 正道"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"吉崎, 智一"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Activation-induced cytidine deaminase (AID) and apolipoprotein B mRNA-editing catalytic polypeptide 3 (A3) family are cytidine deaminases that play critical roles in B-cell maturation, antiviral immunity and carcinogenesis. Adenoids and palatine tonsils are secondary lymphoid immune organs, in which AID and A3s are thought to have several physiological or pathological roles. However, the expression of AID or A3s in these organs has not been investigated. Therefore, we investigated the expression profiles of AID and A3s, using 67 samples of adenoids and palatine tonsils from patients, with reverse transcription quantitative polymerase chain reaction (RT-qPCR) and immunohistochemical analyses. AID and A3s expression levels in the adenoids and the palatine tonsils of the same individual significantly correlated with each other. Of note, AID expression level in the adenoids negatively correlated with the age (r = −0.373, P = 0.003). The younger group with adenoid vegetation and tonsillar hypertrophy showed more abundant AID expression than the older group with recurrent tonsillitis and peritonsillar abscesses (P = 0.026). Moreover, immunohistochemical analysis revealed the distribution of AID and A3s in the epithelial cells as well as germinal centres. The localisation of AID expression and its relation to age may contribute to adenoid vegetation and inflammation.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Ministry of Education, Culture, Sports, Science and Technology B23390396,A24689064","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053819","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-017-18732-w","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/articles/s41598-017-18732-w"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41598-017-18732-w","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2018 The Author(s)."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Seishima, Noriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Satoru"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Wakaea, Kousho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakisaka, Naohiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Kobayashi, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kano, Makoto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Moriyama-Kita, Makiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakanishi, Yosuke"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Endo, Kazuhira"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Imoto, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Kazuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugimoto, Hisashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatano, Miyako"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ueno, Takayoshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Koura, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Kouichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Muramatsu, Masamichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoshizaki, Tomokazu"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-05"}],"displaytype":"detail","filename":"ME-PR-KITAMURA-K-18732-w.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KITAMURA-K-18732-w.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47493/files/ME-PR-KITAMURA-K-18732-w.pdf"},"version_id":"173f9ab6-fe50-4c96-9e59-de914ab67904"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils"}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-05"},"publish_date":"2019-04-05","publish_status":"0","recid":"47493","relation_version_is_last":true,"title":["Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T16:33:45.912344+00:00"}