{"created":"2023-07-27T06:53:09.759584+00:00","id":47494,"links":{},"metadata":{"_buckets":{"deposit":"e564f460-1194-4a81-9f42-e7533b2227e0"},"_deposit":{"created_by":18,"id":"47494","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47494"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047494","sets":["1132:1133:1134"]},"author_link":["2011","84370","84382","24303","84208","79","24080","84222","1289","1721","80081","84371","84375","31","45593","84376","84407","73848","84383","78713","84387","84380","80080","84369","449","84209","2482","21455"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9745","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"},{"bibliographic_title":"8","bibliographic_titleLang":"en"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西山, 智明"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"近藤, 悟"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"加瀬, 希奈"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"喜多村, 晃一"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"中村, 充宏"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"藤原, 浩"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"吉崎, 智一"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"田嶋, 敦"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"村松, 正道"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations), a unique feature of mutations induced by APOBECs, are found in mtDNA from cervical dysplasia and oropharyngeal cancers. In vitro, we found that APOBEC3A (A3A) and 3B (A3B) expression, as well as mtDNA hypermutation, were induced in a cervical dysplastic cell line W12 when cultured in a differentiating condition. The ectopic expression of A3A or A3B was sufficient to hypermutate mtDNA. Fractionation of W12 cell lysates and immunocytochemical analysis revealed that A3A and A3B could be contained in mitochondrion. These results suggest that mtDNA hypermutation is induced upon keratinocyte differentiation, and shed light on its molecular mechanism, which involves A3s. The possible involvement of mtDNA hypermutations in carcinogenesis is also discussed. © 2018 The Author(s).","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053820","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-018-27930-z","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/articles/s41598-018-27930-z"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41598-018-27930-z","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2018 The Author(s)."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wakaea, Kousho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishiyama, Tomoaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kondo, Satoru"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Izuka, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Que, Lusheng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chen, Cong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kase, Kina"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kitamura, Kouichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Md , Monjurul"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Zhe"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ahasan, Md Monjurul"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Mitsuhiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Fujiwara, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoshizaki, Tomokazu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hosomochi, Kazuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tajima, Atsushi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Nakahara, Tomomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kiyono, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muramatsu, Masamichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-05"}],"displaytype":"detail","filename":"ME-PR-KITAMURA-K-27930-z.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KITAMURA-K-27930-z.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47494/files/ME-PR-KITAMURA-K-27930-z.pdf"},"version_id":"0453e700-2f76-430a-8d7f-b0172d6aa472"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation"}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-05"},"publish_date":"2019-04-05","publish_status":"0","recid":"47494","relation_version_is_last":true,"title":["Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T08:47:46.846263+00:00"}