@article{oai:kanazawa-u.repo.nii.ac.jp:00047519,
 author = {山本, 靖彦 and 棟居, 聖一 and 古原, 和美 and 堀, 修 and 白石, 昌武 and 尾﨑, 紀之 and 吉川, 陽文 and 中田, 光俊 and 東田, 陽博 and Yamamoto, Yasuhiko and Liang, Mingkun and Munesue, Seiichi and Deguchi, Kisaburo and Harashima, Ai and Furuhara, Kazumi and Yuhi, Teruko and Zhong, Jing and Akther, Shirin and Goto, Hisanori and Eguchi, Yuya and Kitao, Yasuko and Hori, Osamu and Shiraishi, Yoshitake and Ozaki, Noriyuki and Shimizu, Yu and Kamide, Tomoya and Yoshikawa, Akifumi and Hayashi, Yasuhiko and Nakada, Mitsutoshi and Lopatina, Olga and Gerasimenko, Maria and Komleva, Yulia and Malinovskaya, Natalia and Salmina, Alla B. and Asano, Masahide and Nishimori, Katsuhiko and Shoelson, Steven E. and Yamamoto, Hiroshi and Higashida, Haruhiro},
 journal = {Communications Biology},
 month = {Feb},
 note = {Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal bonding behaviours. Mice lacking secreted oxcytocin (Oxt -/-, Cd38 -/-) or its receptor (Oxtr -/-) fail to nurture. Normal maternal behaviour is restored by peripheral oxcytocin replacement in Oxt -/- and Cd38 -/-, but not Oxtr -/- mice, implying that circulating oxcytocin crosses the blood-brain barrier. Exogenous oxcytocin also has behavioural effects in humans. However, circulating polypeptides are typically excluded from the brain. We show that oxcytocin is transported into the brain by receptor for advanced glycation end-products (RAGE) on brain capillary endothelial cells. The increases in oxcytocin in the brain which follow exogenous administration are lost in Ager -/- male mice lacking RAGE, and behaviours characteristic to abnormalities in oxcytocin signalling are recapitulated in Ager -/- mice, including deficits in maternal bonding and hyperactivity. Our findings show that RAGE-mediated transport is critical to the behavioural actions of oxcytocin associated with parenting and social bonding., 30820471, 金沢大学医薬保健研究域医学系},
 title = {Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice},
 volume = {2},
 year = {2019}
}