{"created":"2023-07-27T06:53:10.908175+00:00","id":47523,"links":{},"metadata":{"_buckets":{"deposit":"9c924ab5-e70d-47a9-9184-c2b57c48067e"},"_deposit":{"created_by":18,"id":"47523","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47523"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047523","sets":["1132:1133:1134"]},"author_link":["100","84605","78961","24841","2474","84617","78959","78962","11754","84611","2735","84619","84609","84616","24836","77011","22247","84618","151","84612","84610"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"4634","bibliographicPageStart":"4627","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Oncology Letters"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"棟居, 聖一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"原島, 愛"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"武内　, 章彦"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"土屋, 弘行"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"山本, 靖彦"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Receptor for advanced glycation end-products (RAGE) is a pattern recognition receptor implicated in the pathogenesis of certain types of cancer. In the present study, papaverine was identified as a RAGE inhibitor using the conversion to small molecules through optimized‑peptide strategy drug design system. Papaverine significantly inhibited RAGE‑dependent nuclear factor κ‑B activation driven by high mobility group box‑1, a RAGE ligand. Using RAGE‑ or dominant‑negative RAGE‑expressing HT1080 human fibrosarcoma cells, the present study revealed that papaverine suppressed RAGE‑dependent cell proliferation and migration dose‑dependently. Furthermore, papaverine significantly inhibited cell invasion. The results of the present study suggested that papaverine could inhibit RAGE, and provided novel insights into the field of RAGE biology, particularly anticancer therapies.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 6 months","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053847","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ol.2018.7902","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.spandidos-publications.com/10.3892/ol.2018.7902"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.spandidos-publications.com/10.3892/ol.2018.7902","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2018, Spandidos Publications. All rights reserved."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1792-1074","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"El‑Far, Ali Hafez Ali MohammedTsuchiya Hiroshi Yamamoto Hazem M.E. Shaheen Yasser S. 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