{"created":"2023-07-27T06:53:11.541014+00:00","id":47549,"links":{},"metadata":{"_buckets":{"deposit":"b69b6efb-5e88-4ba7-9a5d-c282f154b534"},"_deposit":{"created_by":3,"id":"47549","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"47549"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047549","sets":["1132:1137:1270:3671"]},"author_link":["458","84780"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"102","bibliographicPageStart":"98","bibliographicVolumeNumber":"127","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"},{"bibliographic_title":"Journal of the Juzen Medical Society","bibliographic_titleLang":"en"}]}]},"item_7_creator_34":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimada, Tsutomu"}],"nameIdentifiers":[{}]}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"薬物療法は，手術療法，放射線療法または近年注目が集まっている免疫療法と並んで重要な治療法の１つであり，各種疾患の治療のみならず予防を目的に多くの患者に対して広く用いられている．薬物療法は多大なる有用性を有する反面，忘れてはならないものに副作用がある．副作用は，時として治療の中断や重篤な有害事象さらには死をもたらす原因になったり，また医薬品の市場撤退による企業や患者への不利益に繋がったりすることからも，体系的で継続的なモニタリングによる早期発見や対応が重要となる．\n　副作用発症のメカニズムは大きく2つに分けることができ，体質等に関連する細胞障害や薬物アレルギー反応によるものと，薬物の血中濃度が有効域を超え毒性域まで達することによるものがある．前者のアレルギー反応等を原因とする副作用は，用量との関係性がなく，また特定の医薬品で一部の人に対して特異的に発症することから全てを把握することが難しく対応に苦慮することが多い．一方後者で用量依存的に発症する副作用については血中濃度や各種検査値をモニタリングすることによりコントロールすることが可能と考えられている．","subitem_description_type":"Abstract"}]},"item_7_heading_33":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"総説","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"Reviews","subitem_heading_language":"en"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053873","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会 "}]},"item_7_publisher_19":{"attribute_name":"出版者（別名）","attribute_value_mlt":[{"subitem_publisher":"The Juzen Medical Society Kanazawa University"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397 ","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"嶋田, 努"}],"nameIdentifiers":[{"nameIdentifier":"458","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90409384","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90409384"},{"nameIdentifier":"90409384","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000090409384"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-01"}],"displaytype":"detail","filename":"AN00044397-127-3-98-102.pdf","filesize":[{"value":"806.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"AN00044397-127-3-98-102.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47549/files/AN00044397-127-3-98-102.pdf"},"version_id":"58f8c21d-7bb8-4144-a0c8-d43fab272d26"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"安心 ･ 安全な薬物療法を実施するために－薬物動態学的な観点から－","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"安心 ･ 安全な薬物療法を実施するために－薬物動態学的な観点から－"},{"subitem_title":"Management for effective and safety pharmacotherapy -From the view of pharmacokinetics–","subitem_title_language":"en"}]},"item_type_id":"7","owner":"3","path":["3671"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-15"},"publish_date":"2019-04-15","publish_status":"0","recid":"47549","relation_version_is_last":true,"title":["安心 ･ 安全な薬物療法を実施するために－薬物動態学的な観点から－"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T16:33:06.634523+00:00"}