{"created":"2023-07-27T06:53:17.682588+00:00","id":47733,"links":{},"metadata":{"_buckets":{"deposit":"78939eea-2d4a-401e-9aa9-48f43f89df96"},"_deposit":{"created_by":18,"id":"47733","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47733"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047733","sets":["2812:2813:2815"]},"author_link":["85176","85177"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-09-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"がんは多様な性質を持つがん細胞から構成されており、治療への感受性も細胞ごとに異なる。がんにはがん幹細胞が存在するとされており、そこから実際のがん細胞が生じる。従って、がんの理解にはがん幹細胞を理解することが不可欠である。\nヒト肝臓がんではEpCAM陽性とCD90陽性の異なるタイプのがん幹細胞が知られており、両タイプの相違は造腫瘍性や浸潤・転移などの病態に反映される。本研究ではがんの悪性形質を制御する膜型マトリックスメタロプロテアーゼ（MT1-MMP）と本分子により駆動される分子経路の要となる分子の発現と機能を二つのタイプのがん幹細胞で発現していることを確認した。","subitem_description_type":"Abstract"},{"subitem_description":"Cancer is composed of cancer cells with various properties, and the sensitivity to treatment also varies from cell to cell. Cancer stem cells are believed to be present, from which actual cancer cells arise. Therefore, understanding cancer stem cells is essential to understanding cancer.\nIn human liver cancer, different types of cancer stem cells of EpCAM-positive and CD90-positive are known, and the difference between both types is reflected in the pathogenesis such as tumorigenicity, invasion and metastasis. In this study, we confirmed two types of the cancer stem cells express express membrane-type matrix metalloproteinase (MT1-MMP), which controls malignant characteristics of cancer, and the key molecules of the molecular pathway driven by this molecule are functional in the cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16H04695, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「肝細胞がんの多様性・変幻性におけるMT1-MMP依存性分子経路の解析」研究成果報告書　課題番号16H04695\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H04695/16H04695seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054056","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10154634"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10154634","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04695/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04695/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H04695/16H04695seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H04695/16H04695seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-17"}],"displaytype":"detail","filename":"ME-PR-SHIMIZU-M-kaken 2019-5p.pdf","filesize":[{"value":"165.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SHIMIZU-M-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47733/files/ME-PR-SHIMIZU-M-kaken 2019-5p.pdf"},"version_id":"13bff39c-d99a-47f5-832b-412b0a74493f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞がんの多様性・変幻性におけるMT1-MMP依存性分子経路の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞がんの多様性・変幻性におけるMT1-MMP依存性分子経路の解析"},{"subitem_title":"Analysis of MT1-MMP-dependent molecular pathways in the diversity and transformation of hepatocellular carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-17"},"publish_date":"2020-04-17","publish_status":"0","recid":"47733","relation_version_is_last":true,"title":["肝細胞がんの多様性・変幻性におけるMT1-MMP依存性分子経路の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:40:16.376390+00:00"}