{"created":"2023-07-27T06:53:17.727247+00:00","id":47736,"links":{},"metadata":{"_buckets":{"deposit":"e3c7435e-c963-4636-b96e-3a2b2b8df2df"},"_deposit":{"created_by":18,"id":"47736","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47736"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047736","sets":["2812:2813:2815"]},"author_link":["583","85180"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝内胆管癌は原発性肝癌の中で肝細胞癌に次いで2番目に頻度が多く、近年では世界的な患者数の増加傾向が見られている。近年の遺伝子・分子生物学的研究により、肝内胆管癌の亜分類が提唱されており、これらは個別治療に重要である。今回我々は腫瘍糖代謝が小型胆管癌では強い亢進が見られないことを免疫組織化学的に明らかにし、これらがFDG-PET検査で確認出来ることを見いだした。またIDH1/2変異を有するものはMRI検査において高ADC値を呈することを見いだした。","subitem_description_type":"Abstract"},{"subitem_description":"Intrahepatic cholangiocarcinoma is the second most frequent primary liver cancer after hepatocellular carcinoma, and in recent years the worldwide trend for an increasing number of patients has been observed. Recent gene and molecular biological researches have proposed a subclassification of intrahepatic cholangiocarcinoma, which is important for personalized medicine. Here, we clarified by immunohistochemistry that tumor glucose metabolism was not strongly enhanced in small duct type of cholangiocarcinoma, and found that these can be confirmed by FDG-PET examination. We also found that those with IDH1 / 2 mutations show high ADC values rather than IDH1/2 wild type on MRI examination.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K10272, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「肝内胆管癌の遺伝子・分子生物学的機構に基づいたイメージバイオマーカーの研究」研究成果報告書　課題番号16K10272\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10272/16K10272seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054059","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院放射線科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80547175"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80547175","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10272/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10272/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10272/16K10272seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10272/16K10272seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-17"}],"displaytype":"detail","filename":"HO-PR-KOZAKA-K-kaken 2019-5p.pdf","filesize":[{"value":"470.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KOZAKA-K-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47736/files/HO-PR-KOZAKA-K-kaken 2019-5p.pdf"},"version_id":"1de31568-ceb5-4e0b-b894-ed7dd0a62856"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝内胆管癌の遺伝子・分子生物学的機構に基づいたイメージバイオマーカーの研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝内胆管癌の遺伝子・分子生物学的機構に基づいたイメージバイオマーカーの研究"},{"subitem_title":"Image biomarkers of intrahepatic cholangiocarcinoma based on genetic and biomolecular phenotypes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-17"},"publish_date":"2020-04-17","publish_status":"0","recid":"47736","relation_version_is_last":true,"title":["肝内胆管癌の遺伝子・分子生物学的機構に基づいたイメージバイオマーカーの研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:40:14.941342+00:00"}