{"created":"2023-07-27T06:53:17.905001+00:00","id":47751,"links":{},"metadata":{"_buckets":{"deposit":"3a403f99-8396-4536-89bb-17bbe89828dd"},"_deposit":{"created_by":18,"id":"47751","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47751"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047751","sets":["2812:2813:2817"]},"author_link":["1166","21459"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"去勢抵抗性前立腺癌（CRPC）に対する新規治療法の確立には，再燃メカニズムの解明は必要不可欠である．共にユビキチン-プロテアソーム系によって制御される転写因子NF-kappa Bのシグナル伝達系と小胞体ストレス応答系という新たな観点から前立腺癌の再燃メカニズムの解明を試みた．再燃メカニズムの１つとして，NF-kappa Bの恒常的な活性化と小胞体ストレスからの継続的な回避が示されたと共に，ユビキチン-プロテアソーム系を創薬標的とした治療戦略がCRPCに対する新規治療となりうる可能性も示唆された．","subitem_description_type":"Abstract"},{"subitem_description":"Elucidating a comprehensive mechanism through which most patients with advanced prostate cancer have an initial response to androgen deprivation therapy, but eventually progress to a castration-resistant state is critical to establish a novel treatment strategy for castration refractory prostate cancer (CRPC). We investigated the mechanism for the emersion of CRPC from the perspective of ubiquitin-proteasome system regulating both NF-kappa B and unfolded protein response (UPR) activation.　Our study suggested that constitutive NF-kappa B activation and successive escape from endoplasmic reticulum stress might be one of mechanism for CRPC emersion, and that trying development of new drugs with targeting for ubiquitin-proteasome system might be a novel therapeutic strategy for the management of CRPC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26462406, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「去勢抵抗性前立腺癌に対するユビキチン－プロテアソーム系を標的とした治療戦略の確立」研究成果報告書　課題番号26462406\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462406/26462406seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054074","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40334768"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40334768","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462406/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462406/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462406/26462406seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462406/26462406seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-23"}],"displaytype":"detail","filename":"HO-PR-KONAKA-H-kaken 2017-5p.pdf","filesize":[{"value":"207.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KONAKA-H-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47751/files/HO-PR-KONAKA-H-kaken 2017-5p.pdf"},"version_id":"e40e649f-36cf-4adc-9c43-d6e8eaab7e36"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"去勢抵抗性前立腺癌に対するユビキチン－プロテアソーム系を標的とした治療戦略の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"去勢抵抗性前立腺癌に対するユビキチン－プロテアソーム系を標的とした治療戦略の確立"},{"subitem_title":"Establishment of a novel therapeutic strategy for castration-refractory prostate cancer targeting ubiquitin-proteasome system","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-23"},"publish_date":"2019-05-23","publish_status":"0","recid":"47751","relation_version_is_last":true,"title":["去勢抵抗性前立腺癌に対するユビキチン－プロテアソーム系を標的とした治療戦略の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:08:10.585789+00:00"}