{"created":"2023-07-27T06:53:18.838959+00:00","id":47793,"links":{},"metadata":{"_buckets":{"deposit":"85cc8fd9-d63d-4e54-87bf-b14100ebb7fc"},"_deposit":{"created_by":18,"id":"47793","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47793"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047793","sets":["2812:2813:2815"]},"author_link":["76757","259"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では概日リズム制御中枢・視交叉上核(SCN)神経ネットワークが強固で安定した概日リズムを発振するメカニズムについて、研究代表者らがこれまでに開発した遺伝子改変マウスリソースを活用し、その解明を目指した。\nSCNの主要なニューロンタイプの一つ、バソプレシン産生ニューロンが、SCN神経ネットワークによる概日リズム発振やその周期決定に極めて重要であることを明らかにした。また、バソプレシンニューロンや他のタイプのニューロンについて、電気生理学的な性質を明らかにした。これまでバソプレシンニューロンはリズム発振自体には関与しないと考えられており、本研究成果は従来の見解を覆した重要な知見である。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we aimed to understand the neural mechanisms underlying the generation of robust and stable circadian rhythms by the central circadian pacemaker of the suprachiasmatic nucleus (SCN), utilizing genetically-modified mice which we have developed.\nWe found that vasopressin-producing neurons, one of major neuron types in the SCN, play a critical role in the generation of circadian rhythms and the determination of circadian period by the SCN neural network. In addition, we analyzed the electrophysiological characteristics of vasopressin neurons and other types of neurons in the SCN. Before this study, vasopressin neurons had been considered to be dispensable for the generation per se of circadian rhythms by the SCN network. Thus, our findings reversed the conventional views about the role of vasopressin neurons in the central circadian pacemaker.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16H05120, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ニューロンタイプ特異的遺伝子操作による中枢概日ペースメーカーの動作原理の解明」研究成果報告書　課題番号16H05120\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H05120/16H05120seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054115","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20296552"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20296552","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05120/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05120/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H05120/16H05120seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H05120/16H05120seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-17"}],"displaytype":"detail","filename":"ME-PR-MIEDA-M-kaken 2019-5p.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIEDA-M-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47793/files/ME-PR-MIEDA-M-kaken 2019-5p.pdf"},"version_id":"cf361b59-b634-49ea-9bf1-7d33db565a3b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ニューロンタイプ特異的遺伝子操作による中枢概日ペースメーカーの動作原理の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ニューロンタイプ特異的遺伝子操作による中枢概日ペースメーカーの動作原理の解明"},{"subitem_title":"Understanding the neural mechanisms underlying the central circadian pacemaker by neuron type-specific genetic manipulations","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-17"},"publish_date":"2020-04-17","publish_status":"0","recid":"47793","relation_version_is_last":true,"title":["ニューロンタイプ特異的遺伝子操作による中枢概日ペースメーカーの動作原理の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:40:05.640955+00:00"}