{"created":"2023-07-27T06:53:18.882781+00:00","id":47802,"links":{},"metadata":{"_buckets":{"deposit":"c9767823-4ac2-4a01-b64c-3c6c22c137a0"},"_deposit":{"created_by":18,"id":"47802","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47802"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047802","sets":["2812:2813:2815"]},"author_link":["291","78411"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗癌剤の担体であるドラッグデリバリーシステム(DDS)としてナノ粒子が使用されている。磁性を持つナノ粒子を磁力を用いて誘導することにより、効率的に腫瘍への抗癌剤の集積を高めることで治療成績を向上させる実験を行い検証した。インビトロ実験ではチューブに磁石を近接させて行った場合，セミウェッジ状態で注入することが有効であると示された。インビボ実験ではウサギ腫瘍モデルにおいて組織学的な鉄の沈着に差異を生じさせることが可能であった。磁場を用いたDDS注入においては薬剤集積のコントロールにカテーテルを用いた選択的血管造影を組み合わせることでより効率的に薬剤を分布させることが可能となると示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Nano-particles are used as a drug delivery system (DDS) which is a carrier of an anticancer agent. This experiments were conducted to improve treatment results with enhancement of the accumulation of an effective anticancer agent in a tumor by inducing magnetized nanoparticles with magnetic force. In in-vitro experiments, it was found that injection in a semi-wedge state was effective when the magnet was placed close to the tube. The in-vivo experiments used a rabbit tumor model, and differences in iron deposition histologically occurred. Control of drug accumulation combined with selective angiography using a catheter for DDS injection using a magnetic field enables efficient drug distribution.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K10344, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「肝動脈化学塞栓療法における抗癌剤担体ナノ粒子の磁力による集積方法に関する研究」研究成果報告書　課題番号16K10344\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10344/16K10344seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054124","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60436813"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60436813","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10344/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10344/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10344/16K10344seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10344/16K10344seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-17"}],"displaytype":"detail","filename":"ME-PR-MINAMI-T-kaken 2019-6p.pdf","filesize":[{"value":"406.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MINAMI-T-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47802/files/ME-PR-MINAMI-T-kaken 2019-6p.pdf"},"version_id":"bc314d51-3d58-4072-bbae-4ccea6709660"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝動脈化学塞栓療法における抗癌剤担体ナノ粒子の磁力による集積方法に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝動脈化学塞栓療法における抗癌剤担体ナノ粒子の磁力による集積方法に関する研究"},{"subitem_title":"Research on accumulation method of anticancer nanoparticles by magnetic force in hepatic arterial chemoembolization","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-17"},"publish_date":"2020-04-17","publish_status":"0","recid":"47802","relation_version_is_last":true,"title":["肝動脈化学塞栓療法における抗癌剤担体ナノ粒子の磁力による集積方法に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:40:06.983752+00:00"}