{"created":"2023-07-27T06:53:21.165421+00:00","id":47894,"links":{},"metadata":{"_buckets":{"deposit":"0b75699f-ba2a-4811-85da-9bc6a2869a86"},"_deposit":{"created_by":18,"id":"47894","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47894"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047894","sets":["2812:2813:2815"]},"author_link":["78709","85401"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-04-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2017-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"クラインフェルター症候群の表現型異常には余剰X染色体上の遺伝子のうち、不活性化を回避している遺伝子群が原因であると考えられる。クラインフェルター症候群（KS）の患者8名および対象として正常核型の男性4名、女性4名の末梢血より得られたゲノムDNAを用いてマイクロアレイにて全ゲノムのメチル化状態を確認した。X染色体におけるメチル化の一致率はKS群と女性コントロール群との間で99.9%であった。X染色体不活性化を回避していると考えられるプローブは3315個あり、このうちプローブがCpGアイランドに存在し、KSの表現型異常に関与していると考えられる候補遺伝子は117個であった。","subitem_description_type":"Abstract"},{"subitem_description":"Phenotypic abnormality of Kleinfelter's syndrome is considered to be caused by a group of genes on the extra X chromosome that avoid inactivation. The methylation status of the entire genome was analyzed by microarray using genomic DNA obtained from peripheral blood of 8 patients with Kleinfelter syndrome (KS) and 4 males and 4 females with normal karyotype as controls. The concordance rate of methylation in X chromosome was 99.9% between KS group and female control group. There were 3315 probes considered to avoid X chromosome inactivation. Among these, there were 117 candidate genes considered to be involved in the phenotypic abnormality of KS because the probe is present in the CpG island.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K16784, 研究期間(年度):2017-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「クラインフェルター症候群により解き明かされるX染色体の精子形成遺伝子群」研究成果報告書　課題番号17K16784\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K16784/17K16784seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054217","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院泌尿器科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70749168"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70749168","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K16784/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K16784/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K16784/17K16784seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K16784/17K16784seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-17"}],"displaytype":"detail","filename":"HO-PR-IIJIMA-M-kaken 2019-5p.pdf","filesize":[{"value":"95.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-IIJIMA-M-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47894/files/HO-PR-IIJIMA-M-kaken 2019-5p.pdf"},"version_id":"e9bf358d-b489-4fef-af5e-e5c567e528d1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"クラインフェルター症候群により解き明かされるX染色体の精子形成遺伝子群","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"クラインフェルター症候群により解き明かされるX染色体の精子形成遺伝子群"},{"subitem_title":"Spermatogenic genes of X chromosome elucidated by Kleinfelter syndrome","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-17"},"publish_date":"2020-04-17","publish_status":"0","recid":"47894","relation_version_is_last":true,"title":["クラインフェルター症候群により解き明かされるX染色体の精子形成遺伝子群"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:39:59.946290+00:00"}