{"created":"2023-07-27T06:53:21.344449+00:00","id":47904,"links":{},"metadata":{"_buckets":{"deposit":"ca0978c3-93f8-44f9-a0ca-777d27088179"},"_deposit":{"created_by":18,"id":"47904","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47904"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047904","sets":["2812:2813:2815"]},"author_link":["78875","248"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hashimoto, Takanori"}],"nameIdentifiers":[{"nameIdentifier":"78875","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40249959","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40249959"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"統合失調症では抑制性のパルブアルブミン陽性ニューロン（PVニューロン）の変化が前頭前野に存在する。本研究では、げっ歯類でPVニューロン機能を促進するオキシトシン(OXT)の病態への関与を解明するため、ヒト死後脳でOXT受容体(OXTR)の発現を調べた。OXTRの発現は、大脳皮質で低く主に非抑制性ニューロンに認められ、黒質ではドーパミン作動性ニューロンに認められた。黒質ではOXTRの発現に有意な変化はなく、統合失調症の病態におけるOXTの関与は支持されなかった。一方、PVニューロンの機能を担う分子の発現変化は、神経ネットワークを構成する複数の皮質領域に共通して存在することが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"In the prefrontal cortex (PFC) of schizophrenia subjects, local inhibitory neurons that express parvalbumin (PV) appear to be altered. In the rodent cortex, PV neurons were shown to be modulated by neuropeptide oxytocin (OXT) through the OXT receptor (OXTR). In this study, we first aimed to detect OXTR expression in PV neurons in control human subjects. However, OXTR expression was detected mainly in non-inhibitory neurons in the PFC and anterior cingulate cortex. Although OXTR expression was detected in dopamine neurons in the substantia nigra, the mRNA levels were not different between control and schizophrenia subjects. These findings indicate that OXT signaling might not be involved in altered function of PV or dopamine neurons in subjects with schizophrenia. However, the expression levels of other genes in PV neurons, such as GAD1 and KCNS3, were similarly affected in PV neurons across multiple cortical regions in schizophrenia.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16H05372, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「統合失調症の認知機能障害とパルブアルブミン陽性細胞のオキシトシンシグナル」課題番号16H05372\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H05372/16H05372seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054227","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40249959"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40249959","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05372/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05372/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H05372/16H05372seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H05372/16H05372seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"橋本, 隆紀"}],"nameIdentifiers":[{"nameIdentifier":"248","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40249959","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40249959"},{"nameIdentifier":"40249959","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40249959"},{"nameIdentifier":"40249959","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040249959"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-17"}],"displaytype":"detail","filename":"ME-PR-HASHIMOTO-T-kaken 6p.pdf","filesize":[{"value":"579.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HASHIMOTO-T-kaken 6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47904/files/ME-PR-HASHIMOTO-T-kaken 6p.pdf"},"version_id":"55b6f554-c6e4-4050-9187-7ca1f3717641"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"統合失調症の認知機能障害とパルブアルブミン陽性細胞のオキシトシンシグナル","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"統合失調症の認知機能障害とパルブアルブミン陽性細胞のオキシトシンシグナル"},{"subitem_title":"Cognitive Deficits and Oxytocin Signaling in Cortical Parvalbumin Neurons in Schizophrenia","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-17"},"publish_date":"2020-04-17","publish_status":"0","recid":"47904","relation_version_is_last":true,"title":["統合失調症の認知機能障害とパルブアルブミン陽性細胞のオキシトシンシグナル"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:30:18.857037+00:00"}