{"created":"2023-07-27T06:53:23.484427+00:00","id":47974,"links":{},"metadata":{"_buckets":{"deposit":"477eed7d-5342-4c99-9b32-cc3a258d625b"},"_deposit":{"created_by":18,"id":"47974","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47974"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047974","sets":["2812:2813:2815"]},"author_link":["31"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2017-06-30 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 挑戦的研究(萌芽) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒト発生において血液細胞や血管の発生は胎芽本体よりも早い時期から初期絨毛間質内で開始されており、胎芽期の絨毛間質由来の幹細胞が循環系を通して胎児の体内に移行し、生着している可能性がある。そこで本研究は「絨毛由来の幹細胞が胎児本体へ移行し、発生、発達過程での臓器構築に役割を果たすのみならず、成人に至った後も臓器の修復・再生に貢献している」との新しい仮説を立てた。\nその結果、妊娠時に血中のlaeverin陽性細胞が増加することが観察された。また絨毛組織内に新しい血球細胞のnicheの部位が同定された。本研究の成果によって胎児体内循環幹細胞の同定と絨毛内nicheの解析が推進されることとなった。","subitem_description_type":"Abstract"},{"subitem_description":"Since human hematogenesis and angiogenesis in the chorionic villi occur earlier than those in the fetus, it is theoretically possible that chorion-derived stem cells move and migrate fetal tissues by circulation system. We found laeverin-positive undifferentiated cells in the umbilical cord blood. Consequently, we planned this study to prove a novel hypothesis that chorion-derived stem cells settle fetal tissues and contribute to organ regeneration as well as development throughout the total life, using laeverin as a stem cell marker.\nIn this project, we observed laeverin-positive cells increase during pregnancy. We also found the candidate of niche for hematogenesis in the chorion tissues. Our findings will contribute to regulation of stem cell differentiation using ES cells and iPS cells in the future.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K19719, 研究期間(年度):2017-06-30 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「初期ヒト絨毛間質由来の胎児体内循環幹細胞の同定と機能解析」課題番号17K19719\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K19719/17K19719seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054296","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30252456"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30252456","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19719/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19719/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K19719/17K19719seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K19719/17K19719seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-20"}],"displaytype":"detail","filename":"ME-PR-FUJIWARA-H-kaken 2019-6p.pdf","filesize":[{"value":"123.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIWARA-H-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47974/files/ME-PR-FUJIWARA-H-kaken 2019-6p.pdf"},"version_id":"9f85195e-5fe4-40e4-950b-893a7a9032a6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"初期ヒト絨毛間質由来の胎児体内循環幹細胞の同定と機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"初期ヒト絨毛間質由来の胎児体内循環幹細胞の同定と機能解析"},{"subitem_title":"Identification and analysis of circulating embryonic stem cells derived from human chorionic stroma at early stage","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-20"},"publish_date":"2020-04-20","publish_status":"0","recid":"47974","relation_version_is_last":true,"title":["初期ヒト絨毛間質由来の胎児体内循環幹細胞の同定と機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:37:19.820222+00:00"}