{"created":"2023-07-27T06:53:23.575297+00:00","id":47978,"links":{},"metadata":{"_buckets":{"deposit":"aba8284b-c709-42ad-9d3f-f2286124d5a1"},"_deposit":{"created_by":18,"id":"47978","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47978"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047978","sets":["2812:2813:2815"]},"author_link":["310","69907"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胃癌腹膜播種は臓器の線維化が特徴であり、抗がん剤や免疫担当細胞の腫瘍へのデリバリーが阻害され、治療抵抗性である。一方、IL-17A は皮膚筋炎において線維化を誘導することが知られているため、胃癌腹膜播種における線維化にIL-17A が関与しているかどうかを検討した。\n70例の腹膜播種巣において、ほとんどのIL-17A 産生細胞は肥満細胞であり、その浸潤細胞数と線維化の程度は相関していた。正常腹膜中皮細胞にIL-17A を添加すると、E-cadhelin の発現は減弱、α-SMA の発現は増強し、浸潤能は亢進した。この現象はIL-17A がSTAT3 のリン酸化を促進したためであった。 ","subitem_description_type":"Abstract"},{"subitem_description":"Peritoneal metastasis of gastric cancer induce organ fibrosis, which is reason for poor delivery of chemotherapeutic drug and immunocompetent cells. On the other hand, IL-17A is thought to be involved fibrosis in scleroderma. This study identified which cells produce IL-17A and clarified how IL-17A works in cancer microenvironment. Seventy gastric cancer tissues were immuno-stained using anti-IL-17A Ab and anti-mast cell tryptase (MCT) Ab. The degree of tissue fibrosis was also assessed using Azan staining. As in vitro analysis, the effect of IL-17A on human peritoneal mesothelial cells (HPMCs) was examined. Most of IL-17A positive cells also expressed MCT. There was a significant correlation between double positive cell counts and degree of fibrosis. IL-17A decreased E-cadherin expression, increased alpha-SMA expression and invasion ability in HPMCs through enhancement of STAT3 phosphorylation.\nIL-17A contributes EMT in gastric cancer progression and tumor fibrosis. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K10494, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「胃癌腹膜播種における組織内IL-17産生細胞の機能解析と造腫瘍性についての検討」課題番号16K10494\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10494/16K10494seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054300","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10301194"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10301194","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10494/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10494/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10494/16K10494seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10494/16K10494seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-23"}],"displaytype":"detail","filename":"ME-PR-FUSHIDA-Y-kaken 2019-5p.pdf","filesize":[{"value":"757.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUSHIDA-Y-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47978/files/ME-PR-FUSHIDA-Y-kaken 2019-5p.pdf"},"version_id":"764eb0f1-11bc-4e88-9c92-eaca2c1bd4a1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胃癌腹膜播種における組織内IL-17産生細胞の機能解析と造腫瘍性についての検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃癌腹膜播種における組織内IL-17産生細胞の機能解析と造腫瘍性についての検討"},{"subitem_title":"Functional analysis of IL-17 producing cells in peritoneal metastasis of gastric cancer and examination of its tumorigenecity","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-23"},"publish_date":"2020-04-23","publish_status":"0","recid":"47978","relation_version_is_last":true,"title":["胃癌腹膜播種における組織内IL-17産生細胞の機能解析と造腫瘍性についての検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:37:16.232139+00:00"}