{"created":"2023-07-27T06:53:23.620742+00:00","id":47982,"links":{},"metadata":{"_buckets":{"deposit":"bbd192f1-5dcf-4d22-9b7c-0b8d2bc70609"},"_deposit":{"created_by":18,"id":"47982","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47982"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047982","sets":["2812:2813:2816"]},"author_link":["23231"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HPV陽性中咽頭癌の組織では陰性に比してA3A, A3C,A3F, A3Hが高い傾向があった。HPV陽性喉頭乳頭腫では一部でAPOBEC3F発現を認めたものの他はAPOBEC発現は認めなられなかった。中咽頭癌細胞株ではqPCRで検討の結果、A3B,A3Cが高い傾向であった。咽頭細胞株へのHPV遺伝子導入については、トランスフェクション効率が悪く、安定した細胞株を樹立する事が出来ず研究が進まなかった。今回の結果から中咽頭癌で強く発現を認めたAPOBEC familyを同定した。 また、喉頭乳頭腫に関しては正常細胞に潜伏するべく宿主の免疫応答を回避する機構が働いているかもしれない事が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We found that the expression of the apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) 3A, C, F, and H was higher in HPV positive oropharyngeal cancer (OPC) tissues than HPV negative OPC tissues. However, only the A3F was expressed in HPV positive laryngeal papilloma. We failed in conducting the transduction of the HPV gene into oropharyngeal cancer cell line because of low transduction efficiency.\nWe identified APOBEC family highly expressed in oropharyngeal cancer, It was suggested that laryngeal papilloma avoided the host immune response.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K20192, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「HPV陽性中咽頭癌におけるウイルス発癌機構へのAIDの関与」課題番号15K20192\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K20192/15K20192seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054304","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20623648"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20623648","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K20192/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K20192/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K20192/15K20192seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K20192/15K20192seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-06"}],"displaytype":"detail","filename":"ME-PR-NAKANISHI-Y-kaken 2018-4p.pdf","filesize":[{"value":"86.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKANISHI-Y-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47982/files/ME-PR-NAKANISHI-Y-kaken 2018-4p.pdf"},"version_id":"f723630e-ddbe-479a-a0a2-20397f348a81"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"HPV陽性中咽頭癌におけるウイルス発癌機構へのAIDの関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HPV陽性中咽頭癌におけるウイルス発癌機構へのAIDの関与"},{"subitem_title":"Association between activation induced cytidine deaminase and HPV positive oropharyngeal carcinogenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-06"},"publish_date":"2019-06-06","publish_status":"0","recid":"47982","relation_version_is_last":true,"title":["HPV陽性中咽頭癌におけるウイルス発癌機構へのAIDの関与"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:46:54.366046+00:00"}