{"created":"2023-07-27T06:53:23.666584+00:00","id":47986,"links":{},"metadata":{"_buckets":{"deposit":"717c300a-4aef-4596-b795-51938ffdb0fd"},"_deposit":{"created_by":18,"id":"47986","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47986"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047986","sets":["2812:2813:2816"]},"author_link":["72150","319"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、個別化薬物治療を目指し、抗がん剤の複雑な薬物動態に関与する単光子放出断層撮像法を用いた高精度多剤耐性予測法の確立を目的とした。その結果、これまで同じ多剤耐性予測をもたらすと報告されていた[99mTc]sestamibiと[99mTc]tetrofosminにおいて、[99mTc]sestamibiはMDR1とMRP1、一方[99mTc]tetrofosminはMDR1とMRP1-3に親和性があり、各々異なる多剤耐性予測法と成り得ることが判明した。また、[131I]adsterolはBCRPのみに親和性があり、更に高精度な予測法となる可能性を見出した。","subitem_description_type":"Abstract"},{"subitem_description":"We developed high an accuracy multidrug resistance prediction method using SPECT imaging for individualized anticancer therapy. Although [99mTc]sestamibi and [99mTc]tetrofosmin has been reported to be the same method, we clarified that [99mTc]sestamibi had affinity to MDR1 and MRP1, whereas [99mTc]tetrofosmin had affinity to MDR1 and MRP1-3. Thus, these SPECT tracers had different method for multidrug resistance prediction in this study. Additionally, [131I]adsterol was possibility to be higher accuracy multidrug resistance prediction method than [99mTc]sestamibi and [99mTc]tetrofosmin because [131I]adsterol had only affinity to BCRP.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K09949, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「抗がん剤の個別化治療を可能とするSPECTを利用した高精度多剤耐性予測法の確立」課題番号15K09949\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09949/15K09949seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054308","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30444235"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30444235","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09949/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09949/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09949/15K09949seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09949/15K09949seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-06"}],"displaytype":"detail","filename":"ME-PR-KOBAYASHI-M-kaken 2018-5p.pdf","filesize":[{"value":"209.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KOBAYASHI-M-kaken 2018-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47986/files/ME-PR-KOBAYASHI-M-kaken 2018-5p.pdf"},"version_id":"94d738d8-ab63-4895-9478-5a2f49cc8e4c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抗がん剤の個別化治療を可能とするSPECTを利用した高精度多剤耐性予測法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗がん剤の個別化治療を可能とするSPECTを利用した高精度多剤耐性予測法の確立"},{"subitem_title":"Development of high accurary multidrug resistance prediction method using SPECT imaging for individualized anticancer therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-06"},"publish_date":"2019-06-06","publish_status":"0","recid":"47986","relation_version_is_last":true,"title":["抗がん剤の個別化治療を可能とするSPECTを利用した高精度多剤耐性予測法の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:46:52.993709+00:00"}