{"created":"2023-07-27T06:53:23.712433+00:00","id":47988,"links":{},"metadata":{"_buckets":{"deposit":"1592462e-1b58-4b2b-8184-463a8d1d5319"},"_deposit":{"created_by":18,"id":"47988","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47988"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047988","sets":["2812:2813:2815"]},"author_link":["2972","85523"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"新たな大腸発癌経路の同定と分子機構の解明のため、その前癌病変と考えられている大腸鋸歯状腺腫（TSA）を含む大腸鋸歯状病変を対象として、主としてWntシグナル経路に属する遺伝子変異解析、およびメチル化解析を行った。無茎性鋸歯状腺腫（SSA）と比較し、TSAではWntシグナル関連分子の遺伝子変異とSMOC1遺伝子メチル化が高頻度にみられ、SSAとは異なるTSA独自の発癌経路の存在が示された。 ","subitem_description_type":"Abstract"},{"subitem_description":"To clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we examined the mutation and methylation of cancer-associated genes in 78 serrated lesions, including traditional serrated adenomas (TSAs) and sessile serrated adenomas (SSAs). The prevalence of mutations in genes associated with Wnt signaling pathway was significantly higher in TSAs than SSAs. In addition, SMOC1 methylation was detected in 54.1% of TSAs but in no SSAs. These results suggests the presence of distinct carcinogenic pathways of TSAs from other precursor lesions. Furthermore, we detected significant differences in clinicopathological and molecular variables between TSAs with KRAS or BRAF mutation, which may indicate the presence of separate carcinogenic pathways among TSAs. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K09304, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「大腸鋸歯状腺腫を前癌病変とする新たな大腸発癌経路の同定と発癌メカニズムの解明」課題番号16K09304\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K09304/16K09304seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054310","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60345626"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60345626","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09304/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09304/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K09304/16K09304seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K09304/16K09304seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-23"}],"displaytype":"detail","filename":"HO-PR-SAWADA-T-kaken 2019-4p.pdf","filesize":[{"value":"625.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-SAWADA-T-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47988/files/HO-PR-SAWADA-T-kaken 2019-4p.pdf"},"version_id":"93f3cb74-1f75-4445-a4c1-cb066dfd2749"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸鋸歯状腺腫を前癌病変とする新たな大腸発癌経路の同定と発癌メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸鋸歯状腺腫を前癌病変とする新たな大腸発癌経路の同定と発癌メカニズムの解明"},{"subitem_title":"Molecular analysis of traditional serrated adenoma as a candidate precursor of alternative serrated pathway","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-23"},"publish_date":"2020-04-23","publish_status":"0","recid":"47988","relation_version_is_last":true,"title":["大腸鋸歯状腺腫を前癌病変とする新たな大腸発癌経路の同定と発癌メカニズムの解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:37:13.497973+00:00"}