{"created":"2023-07-27T06:53:23.985138+00:00","id":47997,"links":{},"metadata":{"_buckets":{"deposit":"8af2b0af-ac0d-49d0-89ff-4e78c45c38e9"},"_deposit":{"created_by":18,"id":"47997","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"47997"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00047997","sets":["2812:2813:2815"]},"author_link":["190","85541"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大脳皮質に見られる複雑な脳神経回路の形成機構を理解することを目的として、独自に発見した軸索ガイダンス分子Draxinの解析を行った。Draxinの軸索ガイダンス活性に、受容体であるDccとNeogeninに加えて、ヘパラン硫酸プロテオグリカンが重要であることを明らかにした。さらに、高等哺乳動物であるフェレットの大脳皮質神経回路の形成機構の解明を目的として、子宮内電気穿孔法とCRISPR/Cas9システムを組み合わせた遺伝子ノックアウト法を確立した。","subitem_description_type":"Abstract"},{"subitem_description":"To understand molecular mechanisms of the neural circuit formation in the cerebral cortex, we investigated functions of an axon guidance molecule, Draxin. We found that in addition to the receptors Dcc and Neogenin, heparan sulfate proteoglycan was important for the activity of Draxin. Furthermore, for the purpose of elucidating molecular mechanisms of the neural circuit formation in the cerebral cortex of higher mammals, we established a gene knockout method by combining in utero electroporation with the CRISPR/Cas9 system in ferrets.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16H04654, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「軸索ガイダンスに着目した大脳皮質形成機構の解明」課題番号16H04654\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H04654/16H04654seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054319","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00418831"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00418831","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04654/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04654/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H04654/16H04654seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H04654/16H04654seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-14"}],"displaytype":"detail","filename":"ME-PR-SHINMYO-Y-kaken 2020-7p.pdf","filesize":[{"value":"206.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SHINMYO-Y-kaken 2020-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/47997/files/ME-PR-SHINMYO-Y-kaken 2020-7p.pdf"},"version_id":"950b9ecf-29e4-461b-a13f-6dc160fb7f17"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"軸索ガイダンスに着目した大脳皮質形成機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"軸索ガイダンスに着目した大脳皮質形成機構の解明"},{"subitem_title":"Elucidation of developmental mechanisms of the cerebral cortex focusing on axon guidance","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-14"},"publish_date":"2021-05-14","publish_status":"0","recid":"47997","relation_version_is_last":true,"title":["軸索ガイダンスに着目した大脳皮質形成機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:34:43.526687+00:00"}