{"created":"2023-07-27T06:53:25.939237+00:00","id":48108,"links":{},"metadata":{"_buckets":{"deposit":"e1c77d7b-647f-4898-9b32-a100eda84df7"},"_deposit":{"created_by":18,"id":"48108","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48108"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048108","sets":["2812:2813:2815"]},"author_link":["2843","85743"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2017-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"多くのがん細胞に共通したエネルギー代謝特性である解糖系の亢進（Warburg 効果）とオートファジーに焦点を当てて、GSK3βのがん促進作用のメカニズムを検討した。大腸がん細胞ではGSK3βの活性化により、解糖系が亢進すること、及びオートファジー関連転写因子群の発現誘導によってオートファジー活性を亢進していることを見出した。GSK3β阻害剤の併用はオートファジー阻害剤による細胞増殖抑制効果を顕著に増強したことから、がん特有のエネルギー代謝を標的とした治療にGSK3βは格好の候補分子であることが示唆された。 ","subitem_description_type":"Abstract"},{"subitem_description":"We investigated the tumor-promoting mechanisms induced by GSK3β on energy metabolism including Warburg effect and autophagy. Aberrant GSK3β enhanced glycolysis, and led autophagic activation by induction of expression of autophagy-related transcription factors in colon cancer cells. Combined treatment with specific GSK3β inhibitor (AR-A014418) and autophagy inhibitor (hydroxychloroquine) synergistically suppressed proliferation of cancer cells. These results suggest that GSK3β is attractive candidate for cancer energy metabolism targeted therapy.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K15022, 研究期間(年度):2017-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「GSK3βが制御するがん特異的エネルギー獲得機構の解明とがん治療への応用」課題番号17K15022\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K15022/17K15022seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054430","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80635540"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80635540","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K15022/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K15022/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K15022/17K15022seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K15022/17K15022seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-23"}],"displaytype":"detail","filename":"CA-PR-DOMOTO-T-kaken 2019-6p.pdf","filesize":[{"value":"302.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-DOMOTO-T-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48108/files/CA-PR-DOMOTO-T-kaken 2019-6p.pdf"},"version_id":"d1eb987b-0d6c-4e03-9019-025a77c3a417"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"GSK3βが制御するがん特異的エネルギー獲得機構の解明とがん治療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GSK3βが制御するがん特異的エネルギー獲得機構の解明とがん治療への応用"},{"subitem_title":"Exploring biological basis of aberrant cancer energy metabolism induced by GSK3beta toward application to cancer treatment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-23"},"publish_date":"2020-04-23","publish_status":"0","recid":"48108","relation_version_is_last":true,"title":["GSK3βが制御するがん特異的エネルギー獲得機構の解明とがん治療への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:36:59.519190+00:00"}