{"created":"2023-07-27T06:53:26.277390+00:00","id":48126,"links":{},"metadata":{"_buckets":{"deposit":"05207119-6a88-4f97-9539-60b0b5dae1a5"},"_deposit":{"created_by":18,"id":"48126","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48126"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048126","sets":["2812:2813:2815"]},"author_link":["45213"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"進行前立腺癌に対するアンドロゲン除去療法は有効であるが、いずれ無効な状態となる。アンドロゲン受容体シグナルが抑制されることによって、前立腺癌細胞の増殖は抑制されるが、前立腺癌細胞からCCL20が分泌され、癌細胞自身（あるいは近傍の前立腺癌細胞）に作用し、結果的に前立腺癌細胞の転移能を高める可能性が明らかとなった。また転移能が高い前立腺癌細胞からはCCL20が多く分泌されており、CCL20が転移能を高めている可能性が裏付けられた。 ","subitem_description_type":"Abstract"},{"subitem_description":"The curative effects of androgen-deprivation therapy may become severely compromised when the prostate cancer cells develop into a castration-resistant stage. Blockade of androgen-androgen receptor signaling inhibited prostate cancer cell proliferation; however, it could increase metastatic ability of prostate cancer cells via CCL20 by autocrine manner. Prostate cancer cells with high metastatic ability also showed high expression of CCL20, suggesting that CCL20 adds metastatic potential to prostate cancer cells. 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