{"created":"2023-07-27T06:53:26.546349+00:00","id":48136,"links":{},"metadata":{"_buckets":{"deposit":"d70a26be-3d90-40d5-a6d5-06e8826a6048"},"_deposit":{"created_by":18,"id":"48136","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48136"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048136","sets":["2812:2813:2818"]},"author_link":["79652","200"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は，“植物の眼”ともいえる光受容色素タンパク質フィトクロムの機能解明を，酸化的官能基化を基盤とする立体固定型フィトクロム発色団の化学合成から集中的に検討した。その結果，DDQを用いるC環型ピロールの酸化において，側鎖α位の選択的酸化を実現することができ，これを応用して７員環，および８員環固定型15E-anti立体固定発色団の合成に目処をつけた。一方，ＣＤ環ジピロールのNBSによる酸化によりメソ位が選択的に臭素化されることを見出し，この臭素化体に，Grignard試薬を作用させると収率よく炭素鎖を導入できることを見出し，15E固定型フィトクロム発色団の合成を達成することができた。","subitem_description_type":"Abstract"},{"subitem_description":"Phytochromes play critical roles in various light-regulated processes through photoconversion from Pr to Pfr is thought to be a Z-to-E isomerization around the C15-C16 double bond. To elucidate the functions of phytochromes, the sterically locked tetrapyrrole chromophores were synthesized especially via oxidative functionalization of pyrrole compounds. Oxidation of the C-ring moiety with DDQ afforded the corresponding aldehyde, which was applied to the synthesis of the sterically locked seven-membered and 8-membered 15E-anti CD-ring component. Oxidation of the CD-ring component with NBS at the meso-position was achieved to give the corresponding meso-bromo CD-ring compounds. The introduction of carbon skeleton was realized by treatment with Grignard reagents. Finally, the substrate with leaving group at omega-position was converted to a meso-anchored sterically fixed 15E-chromophore.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25620028, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「立体固定型発色団合成を基盤とするフィトクロムの構造と機能の解明」課題番号:25620028\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25620028/25620028seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学理工研究域物質化学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054458","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80193853"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80193853","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25620028/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25620028/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25620028/25620028seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25620028/25620028seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-17"}],"displaytype":"detail","filename":"SC-PR-UKAJI-Y-kaken 2016-4p.pdf","filesize":[{"value":"271.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"SC-PR-UKAJI-Y-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48136/files/SC-PR-UKAJI-Y-kaken 2016-4p.pdf"},"version_id":"ce67c850-48bb-42bb-b54e-7402b09c5e92"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"立体固定型発色団合成を基盤とするフィトクロムの構造と機能の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"立体固定型発色団合成を基盤とするフィトクロムの構造と機能の解明"},{"subitem_title":"Elucidation of Phytocrome Functions Based on Syntheses of Sterically Locked Phytochrome Chromophores","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-17"},"publish_date":"2019-06-17","publish_status":"0","recid":"48136","relation_version_is_last":true,"title":["立体固定型発色団合成を基盤とするフィトクロムの構造と機能の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:49:16.953804+00:00"}