{"created":"2023-07-27T06:53:26.680693+00:00","id":48140,"links":{},"metadata":{"_buckets":{"deposit":"9a36ee8b-7e3d-47a5-b5b2-93541e33a3d2"},"_deposit":{"created_by":18,"id":"48140","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48140"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048140","sets":["2812:2813:2816"]},"author_link":["85783","85781"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"これまでにがん悪性化機構として上皮間葉転換（EMT）に着目し、エピジェネティック制御因子であるポリコーム抑制複合体（PRC2）が、上皮系遺伝子の発現を抑制することで、EMTを誘導することを示した。本研究では、PRC2が標的遺伝子座へ近づく際に、長鎖非コードRNA（タンパク質をコードしない200塩基以上のRNA）の1つであるMEG3がガイドとして機能することを示唆する結果を得た。本研究成果は、長鎖非コードRNAが関わるがん悪性化機構の理解につながることが期待される。","subitem_description_type":"Abstract"},{"subitem_description":"We have focused on epithelial-mesenchymal transition (EMT) as a mechanism of cancer progression and reported that polycomb repressive complex 2 (PRC2), which is one of epigenetic regulators, induces EMT by repressing the expression of epithelial genes. In this study, we proposed that MEG3 long noncoding RNA guides PRC2 to its target gene loci. These results contribute to understanding of long noncoding RNA involved in cancer progression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K19030, 研究期間(年度):2016-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「上皮間葉転換(EMT)を制御する長鎖非コードRNAの機能解析」課題番号16K19030\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19030/16K19030seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054462","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80507434"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80507434","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19030/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19030/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19030/16K19030seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19030/16K19030seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-17"}],"displaytype":"detail","filename":"CA-PR-TERASHIMA-M-kaken 2018-4p.pdf","filesize":[{"value":"658.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TERASHIMA-M-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48140/files/CA-PR-TERASHIMA-M-kaken 2018-4p.pdf"},"version_id":"099a64b0-beb3-4990-85c7-784e84cba8e6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"上皮間葉転換(EMT)を制御する長鎖非コードRNAの機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"上皮間葉転換(EMT)を制御する長鎖非コードRNAの機能解析"},{"subitem_title":"Functional analysis of long noncoding RNAs that regulate epithelial-mesenchymal transition","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-17"},"publish_date":"2019-06-17","publish_status":"0","recid":"48140","relation_version_is_last":true,"title":["上皮間葉転換(EMT)を制御する長鎖非コードRNAの機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:46:47.959378+00:00"}