{"created":"2023-07-27T06:53:26.951264+00:00","id":48146,"links":{},"metadata":{"_buckets":{"deposit":"37e9dac5-6180-44e1-b915-4b8c14597f9e"},"_deposit":{"created_by":18,"id":"48146","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48146"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048146","sets":["2812:2813:2815"]},"author_link":["457","85792"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"慢性骨髄性白血病（CML）の発症初期の骨髄内において、白血病幹細胞から分化誘導する好塩基球様の白血病細胞が、幹細胞抑制作用を示す炎症性ケモカインCCL3を恒常的に産生し、正常造血幹・前駆細胞の増殖を選択的に抑制することで白血病幹細胞の優先的な増殖、さらにはCML病態の増悪・進展に寄与していることを明らかにした。\nこの分子・細胞機序の治療標的としての可能性を検討したところ、CML発症初期過程における好塩基球様の白血病細胞の選択的除去、もしくはCCL3阻害剤の投与によって、効果的なCMLの発症予防効果が認められた。 ","subitem_description_type":"Abstract"},{"subitem_description":"Basophilia is a frequently observed hematological abnormality in chronic myeloid leukemia (CML), but its pathophysiological roles are undefined. In this study, we demonstrated that basophil-like leukemia cells proliferate and constitutively express an inflammatory chemokine, CCL3, in the bone marrow of mice developing CML. Moreover, CCL3 preferentially inhibits the proliferation of normal hematopoietic stem/progenitor cells, thereby facilitating the dominant proliferation of leukemia stem cells during the initiation process of CML development. We further demonstrated that the depletion of basophil-like leukemia cells or the oral-administration of CCL3 inhibitor efficiently prevented the CML development. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K08733, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「慢性骨髄性白血病における炎症性ケモカインCCL3の病態生理学的役割の解明」課題番号16K08733\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08733/16K08733seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054468","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00452095"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00452095","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08733/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08733/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08733/16K08733seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08733/16K08733seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-23"}],"displaytype":"detail","filename":"CA-PR-BABA-T-kaken 2019-4p.pdf","filesize":[{"value":"233.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-BABA-T-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48146/files/CA-PR-BABA-T-kaken 2019-4p.pdf"},"version_id":"536226ff-0fe4-4287-b0f5-fe225e4d7e9a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"慢性骨髄性白血病における炎症性ケモカインCCL3の病態生理学的役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性骨髄性白血病における炎症性ケモカインCCL3の病態生理学的役割の解明"},{"subitem_title":"Pathophysiological role of inflammatory chemokine, CCL3, in chronic myeloid leukemia","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-23"},"publish_date":"2020-04-23","publish_status":"0","recid":"48146","relation_version_is_last":true,"title":["慢性骨髄性白血病における炎症性ケモカインCCL3の病態生理学的役割の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:36:47.396902+00:00"}