{"created":"2023-07-27T06:53:27.017855+00:00","id":48148,"links":{},"metadata":{"_buckets":{"deposit":"b1d6b777-fc32-452a-a2d9-0c95ba44d613"},"_deposit":{"created_by":18,"id":"48148","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48148"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048148","sets":["2812:2813:2815"]},"author_link":["260","85793"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"DICの本態は、著しい凝固活性化と微小血栓多発であり、進行すると不可逆的な臓器障害や出血症状をきたす。予後改善のためには、適切な診断基準の作成と病態に応じた早期の治療介入が必要である。DICモデルを用いた我々の検討では、充分な抗凝固療法を行っても、特に炎症の強い病態では微小循環障害や内皮障害に起因する臓器障害を伴うDICの進展は不可逆的であり、凝固活性化以外の要素が病態に深く関与していると考えられる。血管作動性物質は、DICの循環動態に影響を与える可能性が高いが、その意義は不明である。DICモデルでの血管作動性物質の意義については今後とも検討を継続する。 ","subitem_description_type":"Abstract"},{"subitem_description":"The essential features of DIC are marked coagulation activation and multiple microthrombi, which, when advanced, cause irreversible organ damage and bleeding symptoms. The development of appropriate diagnostic criteria and early intervention according to the disease state are necessary for improvement of prognosis. In our study using the DIC model, even if sufficient anticoagulation therapy is performed, the progression of DIC with organ damage caused by microcirculatory disturbance and endothelial disturbance is irreversible especially in the disease state with strong inflammation, and elements other than coagulation activation seem to be deeply involved in the disease state. Vasoactive substances are likely to affect the hemodynamics of DIC, but their significance is unclear. The significance of vasoactive substances in the DIC model will be continuously examined in future. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K11396, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「DIC病態における炎症と凝固のクロストークと血管作動性物質の役割」課題番号16K11396\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K11396/16K11396seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054470","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院高密度無菌治療部"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60192936"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60192936","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11396/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11396/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K11396/16K11396seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K11396/16K11396seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-23"}],"displaytype":"detail","filename":"HO-PR-ASAKURA-H-kaken 2019-5p.pdf","filesize":[{"value":"168.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-ASAKURA-H-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48148/files/HO-PR-ASAKURA-H-kaken 2019-5p.pdf"},"version_id":"ad5aece0-a896-4f40-9d31-adb62adcdc3a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"DIC病態における炎症と凝固のクロストークと血管作動性物質の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DIC病態における炎症と凝固のクロストークと血管作動性物質の役割"},{"subitem_title":"Crosstalk of Inflammation and Coagulation and the Role of Vasoactive Substances in DIC Pathology","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-23"},"publish_date":"2020-04-23","publish_status":"0","recid":"48148","relation_version_is_last":true,"title":["DIC病態における炎症と凝固のクロストークと血管作動性物質の役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:36:46.083552+00:00"}