{"created":"2023-07-27T06:53:30.103706+00:00","id":48244,"links":{},"metadata":{"_buckets":{"deposit":"f777acf7-c358-4f21-8e53-4aa4f0b1122d"},"_deposit":{"created_by":18,"id":"48244","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48244"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048244","sets":["2812:2813:2816"]},"author_link":["85956","85957"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、制御性B細胞が増加しているマウス（B細胞特異的PTEN欠損マウス）を用いて悪性黒色腫の増生および腫瘍浸潤細胞を解析した。B細胞特異的PTEN欠損マウスでは悪性黒色腫が有意に増大し、腫瘍に浸潤する制御性B細胞が増加していた。一般に制御性B細胞はMarginal zone B細胞とB1 B細胞の2つのサブセットから成るが、腫瘍に浸潤している制御性B細胞はB1 B細胞であった。そこでB1 B細胞を悪性黒色腫細胞と混合して野生型マウスに移入したところ、非混合群および非B1 B細胞混合群と比べ腫瘍増生が増大した。以上より制御性B細胞は悪性黒色腫に対する腫瘍免疫反応を抑制していると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"In tumor immunity, the participation of IL-10-producing regulatory B cell (Breg) which suppresses several immune responses is unclear. Here we demonstrated that B16F10 melanoma growth was increased in B cell-specific phosphatase and tensin homolog (PTEN)-deficient mice in which Breg subset is expanded. More than 50% of the tumor-infiltrating B cells consisted of Bregs in both B cell-specific PTEN-deficient mice and control mice. The number of tumor-infiltrating Bregs was significantly increased in B cell-specific PTEN-deficient mice. Although we have previously identified 2 Breg subsets derived from marginal zone Bregs and B1 Bregs, most of tumor-infiltrating Bregs consisted of B1 Bregs but not MZ Bregs. Adoptive transfer of B1 B cells increased melanoma growth while non-B1 B cells had no effect. Thus, B1 Bregs negatively regulate tumor immunity against melanoma.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K18449, 研究期間(年度):2016-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「腫瘍免疫におけるRegulatory B細胞の役割についての解析」課題番号16K18449\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18449/16K18449seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院皮膚科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054566","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20746383"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20746383","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18449/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18449/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18449/16K18449seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18449/16K18449seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-27"}],"displaytype":"detail","filename":"HO-PR-KOBAYASHI-T-kaken 2018-5p.pdf","filesize":[{"value":"453.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KOBAYASHI-T-kaken 2018-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48244/files/HO-PR-KOBAYASHI-T-kaken 2018-5p.pdf"},"version_id":"ab299781-2428-4d95-a507-a37766f5287b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍免疫におけるRegulatory B細胞の役割についての解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍免疫におけるRegulatory B細胞の役割についての解析"},{"subitem_title":"A role of regulatory B cell in tumor immunity","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-27"},"publish_date":"2019-06-27","publish_status":"0","recid":"48244","relation_version_is_last":true,"title":["腫瘍免疫におけるRegulatory B細胞の役割についての解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:46:44.789641+00:00"}