{"created":"2023-07-27T06:53:30.648494+00:00","id":48269,"links":{},"metadata":{"_buckets":{"deposit":"fd5d29ba-2bf8-43ca-906e-8c6bb0f4800e"},"_deposit":{"created_by":18,"id":"48269","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48269"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048269","sets":["2812:2813:2819"]},"author_link":["85983","1796"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"癌の浸潤、転移は最も重要な特性であり、癌の浸潤を防ぐことが予後を左右すると思われる。そこで浸潤の初期段階におこる癌細胞間の接着機能の低下、上皮間葉移行(EMT)獲得に着目した。接着因子であるE-cadherinの抑制にて浸潤能、運動能の上昇が認められたことから、結合するbeta-cateninの発現変化を検討すると、核内での発現上昇が認められた。次に、悪性度によるEMTとの関係について検討すると、悪性度が強い細胞でRNA、タンパクの発現を検討した結果、悪性度の強い細胞ではEMTが獲得されている傾向を認めた。","subitem_description_type":"Abstract"},{"subitem_description":"Invasion and the metastasis of cancer are the most important characteristics, and it is thought that it controls prognosis to prevent the invasion of cancer. Therefore I focus attention on the decrease of the adhesion function between the cancer cell for an initial stage of the invasion, and epithelial-mesenchymal transition (EMT). In our previous studies, increace of migration and invasion ability was recognized by knockdown of E-cadherin. Thus we results to be considered altered expression of beta-catenin that binds to E-cadherin, increased in the nucleus was observed. Then, I examined relations with EMT by the malignancy. As a result of having examined expression of protein and RNA with the cell which a malignancy resisted, I recognized the tendency that EMT was acquired with the strong cell of the malignancy.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25861923, 研究期間(年度):2013-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「口腔扁平上皮癌の浸潤・転移における細胞間接着分子の役割」課題番号25861923\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25861923/25861923seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054591","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院歯科口腔外科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70507053"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70507053","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25861923/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25861923/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25861923/25861923seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25861923/25861923seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-27"}],"displaytype":"detail","filename":"HO-PR-KITAHARA-H-kaken 2015-4p.pdf","filesize":[{"value":"267.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KITAHARA-H-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48269/files/HO-PR-KITAHARA-H-kaken 2015-4p.pdf"},"version_id":"72a4bc59-684e-4a52-9099-e5681f77772f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔扁平上皮癌の浸潤・転移における細胞間接着分子の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔扁平上皮癌の浸潤・転移における細胞間接着分子の役割"},{"subitem_title":"Role of the adhesion molecules between the cell in invasion, the metastasis of oral squamous cell carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-27"},"publish_date":"2019-06-27","publish_status":"0","recid":"48269","relation_version_is_last":true,"title":["口腔扁平上皮癌の浸潤・転移における細胞間接着分子の役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:41:42.159730+00:00"}