{"created":"2023-07-27T06:53:30.718319+00:00","id":48271,"links":{},"metadata":{"_buckets":{"deposit":"a1ba0e11-e924-47da-9dda-4adf08f96a77"},"_deposit":{"created_by":18,"id":"48271","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48271"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048271","sets":["2812:2813:2815"]},"author_link":["27221","2408"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"末梢の慢性炎症は、うつ病患者に認められることがある。 本研究は、うつと関連因子の経路を同定することを目的とし、女性集団において血清炎症マーカー、LDL酸化度、脂肪酸、心理的ストレス、抑うつ度（Dep）を調査した。\nLDL酸化度はDepと正の相関を示したが、心理的ストレスとより関係していた。IL-6はDepと正の相関を示したが、その経路は一部LDL酸化度を介していた。 また、ω3脂肪酸は、IL-6およびLDL酸化度とは独立してDepと逆相関した。 さらに、IL-17AはDepの高い者でより高かった。\nうつ病を予防するためのライフスタイル、または症状を軽減させるターゲットの新しい可能性を示した。 ","subitem_description_type":"Abstract"},{"subitem_description":"Low-grade inflammation and oxidative stress are observed in persons with depressive symptoms (Dep). We explored Dep under psychological stress in relation to serum LDL oxidation rate (ox-LDL/LDL), inflammatory markers, and fatty acids (FAs) among female populations. We aimed to identify peripheral factors that are related to Dep.\nSerum ox-LDL/LDL was positively connected with Dep, but was more strongly related to perceived psychological stress. Serum IL-6 was positively concerned with Dep, though the effect was partly intervened by ox-LDL/LDL. Further, serum ω3 FAs were inversely associated with Dep independently of IL-6 or ox-LDL/LDL. In addition, serum IL-17A was higher among high depressive participants. These findings suggest the therapeutic potential of lifestyle targets to alleviate the identified depression risk factors, anti-oxidative therapies, anti-inflammatory therapies and nutritional interventions to prevent depression. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K01787, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「抑うつ状態と末梢の慢性炎症・酸化」課題番号16K01787\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K01787/16K01787seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054593","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20319338"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20319338","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K01787/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K01787/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K01787/16K01787seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K01787/16K01787seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-24"}],"displaytype":"detail","filename":"PH-PR-TSUBOI-H-kaken 2019-4p.pdf","filesize":[{"value":"247.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-TSUBOI-H-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48271/files/PH-PR-TSUBOI-H-kaken 2019-4p.pdf"},"version_id":"c0e4af27-ba3b-4713-ab1d-eb3108a99dc8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抑うつ状態と末梢の慢性炎症・酸化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抑うつ状態と末梢の慢性炎症・酸化"},{"subitem_title":"Inflammation and oxidation in depressive states","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"48271","relation_version_is_last":true,"title":["抑うつ状態と末梢の慢性炎症・酸化"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:36:07.485655+00:00"}