{"created":"2023-07-27T06:53:30.924002+00:00","id":48277,"links":{},"metadata":{"_buckets":{"deposit":"e01c7d37-c2e8-4d84-9af8-6eabc07aabb4"},"_deposit":{"created_by":18,"id":"48277","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48277"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048277","sets":["2812:2813:2815"]},"author_link":["23436","2892"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究課題の研究において、インドシアニングリーンの血管内投与を用いた光音響イメージングは各臓器での血管透過性の評価に用いる事ができた。また腫瘍内においても濃度依存性を示しインドシアニングリーンは定量可能であった。腫瘍における抗腫瘍薬による血管透過性の低下をインドシアニングリーンは検知することができ、その後の腫瘍細胞の縮小をいち早く予測できると考えられた。 ","subitem_description_type":"Abstract"},{"subitem_description":"We demonstrated the applicability of photoacoustic (PA) imaging with indocyanine green (ICG) in a mouse tumor model. It allows safe and real-time imaging acquisition, and unlike common conventional contrast agents such as iodinated and gadolinium based contrast agents, ICG-enhanced PA imaging can less depict the IVC and hypervascular organs such as kidney and liver. The PA signal of ICG was rather enhanced in the interstitial extravascular space of tumors and salivary gland at the early phase after ICG injection. PA imaging with ICG allows for assessment of the early treatment response at a time when there is still no difference in tumor size after anti-VEGF therapy in this tumor model in mice and can directly reflect vascular permeability, which is not feasible at all with other imaging systems. Thus, PA imaging has a potential for the broader application for diagnosis of other pathologies characterized by changes in vascular permeability. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K19812, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「腫瘍血管の成熟性を評価可能な光音響イメージングの腫瘍放射線医学への応用」課題番号16K19812\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19812/16K19812seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054599","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30645130"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30645130","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19812/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19812/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19812/16K19812seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19812/16K19812seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-24"}],"displaytype":"detail","filename":"ME-PR-YOSHIDA-K-kaken 2019-4p.pdf","filesize":[{"value":"153.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YOSHIDA-K-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48277/files/ME-PR-YOSHIDA-K-kaken 2019-4p.pdf"},"version_id":"a7c333eb-c71f-4c41-aa4f-78d40a491c31"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍血管の成熟性を評価可能な光音響イメージングの腫瘍放射線医学への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍血管の成熟性を評価可能な光音響イメージングの腫瘍放射線医学への応用"},{"subitem_title":"Application of photoacuoustic imaging for evaluating tumor vascular maturity","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"48277","relation_version_is_last":true,"title":["腫瘍血管の成熟性を評価可能な光音響イメージングの腫瘍放射線医学への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:36:03.274127+00:00"}