{"created":"2023-07-27T06:53:30.991874+00:00","id":48279,"links":{},"metadata":{"_buckets":{"deposit":"0c23f6a8-e6d8-421c-a218-cf4771e53937"},"_deposit":{"created_by":18,"id":"48279","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48279"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048279","sets":["2812:2813:2815"]},"author_link":["85996","85997"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々はセリンスレオニンキナーゼであるglycogen synthase kinase 3β（GSK3β）に着目し、GKS3βを抑制することで腫瘍細胞の増殖・浸潤が抑制されることを報告している。また、この知見を元にGSK3β阻害作用を有する既存の4種薬剤を用いた第1/Ⅱ相臨床試験を行い、その有効性と安全性を確認したが、4種薬剤の組み合わせを‘CLOVA cocktail’と称し、この有効性をこれまでの研究成果と共に2017年に論文報告した（Oncotarget.2017)。 ","subitem_description_type":"Abstract"},{"subitem_description":"We have reported that inhibition of glycogen synthase kinase 3 beta(GSK3 beta）supresses proliferation of glioblastoma cell.We conducted clinical trial for　recurrent glioblastoma using existing drug with GSK3 beta inhibitory effect,confirmed its efficacy and safety. We named conbination of 4 drugs with GSK3 beta inhibitory effect ‘CLOVA cocktail’and we reported efficacy of the cocktail and results of our research（Oncotarget.2017). ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K10751, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「GSK3βを分子標的とする神経膠芽腫治療の基礎基盤の確立」課題番号16K10751\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10751/16K10751seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054601","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80624874"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80624874","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10751/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10751/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10751/16K10751seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10751/16K10751seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-24"}],"displaytype":"detail","filename":"HO-PR-MIYASHITA-K-kaken 2019-6p.pdf","filesize":[{"value":"119.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-MIYASHITA-K-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48279/files/HO-PR-MIYASHITA-K-kaken 2019-6p.pdf"},"version_id":"84a33161-0c16-49ef-8cf3-b8406cc16ca7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"GSK3βを分子標的とする神経膠芽腫治療の基礎基盤の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GSK3βを分子標的とする神経膠芽腫治療の基礎基盤の確立"},{"subitem_title":"Establishment of glioblastoma therapy targeting for GSK3beta","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"48279","relation_version_is_last":true,"title":["GSK3βを分子標的とする神経膠芽腫治療の基礎基盤の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:36:01.891745+00:00"}