{"created":"2023-07-27T06:53:31.266533+00:00","id":48286,"links":{},"metadata":{"_buckets":{"deposit":"6dce24d9-4579-4899-ba1f-52d5a460e447"},"_deposit":{"created_by":18,"id":"48286","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48286"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048286","sets":["2812:2813:2815"]},"author_link":["86004","86005"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膜輸送体OCTN1の薬物治療学的意義を解明する目的で、OCTN1による神経成熟促進の細胞内メカニズム、およびOCTN1の良好な生体内基質ergothioneine（ERGO）がストレス性精神・神経疾患のバイオマーカーとなる可能性について検討した。その結果、OCTN1を介した細胞内へのERGOの取り込みは神経栄養因子の誘導およびmTORやTrkBシグナルの活性化を介して神経分化や神経成熟を促進することが示された。また、うつ症状の重症度と血中ERGO濃度の間に正の相関傾向があり、ERGOがストレス性精神・神経疾患のバイオマーカーとなる可能性が示された。 ","subitem_description_type":"Abstract"},{"subitem_description":"To clarify the pharmacotherapeutic role of the carnitine/organic cation transporter OCTN1, we examined intracellular mechanisms underlying neuronal differentiation and maturation promoted by OCTN1 and whether the in vivo substrate of OCTN1, ergothioneine (ERGO), is available as a biomarker for depression. OCTN1-mediated ERGO uptake promoted neuronal differentiation and maturation through the induction of neurotrophic factors and the activation of mechanistic target of rapamycin (mTOR) and tropomyosin receptor kinase B (TrkB) signaling. There was a positive correlation between the severity of depressive symptoms and ERGO concentration in the blood, suggesting that ERGO could be used as a biomarker for stress-induced neuropsychiatric disorders including depression. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K08266, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「膜輸送体OCTN1による神経細胞内制御機構解明と精神・神経疾患バイオマーカー探索」課題番号16K08266\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08266/16K08266seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054608","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"高崎健康福祉大学 / 金沢大学医薬保健研究域"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10401895"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10401895","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08266/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08266/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08266/16K08266seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08266/16K08266seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-24"}],"displaytype":"detail","filename":"PH-PR-NAKAMICHI-N-kaken 2019-6p.pdf","filesize":[{"value":"182.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKAMICHI-N-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48286/files/PH-PR-NAKAMICHI-N-kaken 2019-6p.pdf"},"version_id":"26f43f28-c09c-409e-8aee-811b5eeb966c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膜輸送体OCTN1による神経細胞内制御機構解明と精神・神経疾患バイオマーカー探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膜輸送体OCTN1による神経細胞内制御機構解明と精神・神経疾患バイオマーカー探索"},{"subitem_title":"Elucidation of intracellular mechanisms underlying neuronal maturation promoted by solute carrier OCTN1 and biomarker exploration in neuropsychiatric disorders","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"48286","relation_version_is_last":true,"title":["膜輸送体OCTN1による神経細胞内制御機構解明と精神・神経疾患バイオマーカー探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:35:59.099296+00:00"}