{"created":"2023-07-27T06:53:38.518177+00:00","id":48439,"links":{},"metadata":{"_buckets":{"deposit":"27e6f266-3946-4f85-a8b0-dd01ba18e98a"},"_deposit":{"created_by":18,"id":"48439","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48439"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048439","sets":["2812:2813:2817"]},"author_link":["2263","86266"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"骨髄不全症例の約60％で検出されるPNH形質血球をマーカーとして、造血幹細胞の分化造血制御について考察した。患者の骨髄中に存在している様々な造血前駆細胞ごとにPNH形質血球の割合を調べたところ、CMPにおいては10%未満であったのに対して、以降の造血前駆細胞においては末梢血中の骨髄球系細胞とほぼ同等の割合でPNH形質血球が認められた。PNH形質血球の選択的増殖における付加的遺伝子変異を確認するための遺伝子解析では、特定のサイトカインの発現が亢進していることを明らかにした。以上より、ヒト造血の系列は個々の造血幹細胞または骨髄内のサイトカインを含む複合的な因子により規定されると結論付けた。","subitem_description_type":"Abstract"},{"subitem_description":"The regulation of HSC (Haematopietic stem cell) differentiation was assessed by FCM (Flow cytometry) with a marker, PNH (paroxysmal nocturnal hemoglobinuria)-type cell, which was detected in 60 perentage of bone marrow failure patients. As investigated the percentage of PNH-type cell in various lineages of HSPC (haematopoietc stem progenitor cell), PNH-type cells were detected only 10 perentage in CMP (common myelod progenitors) fraction, however, the same percentage was detected in GMP and MEP as myeloid cells in peripheral blood. Additional genetic analysis to check driver mutation genes effect on the selective growth of PNH-type cell revealed the expression of a specific cytokine was enhanced. From the above, I concluded the differentiation of human HSC was regulated by some complicated factors including HSCs or some cytokines in bone marrow.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26860363, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「発作性夜間血色素尿症(PNH)形質を利用したヒト造血幹細胞動態の解明」研究成果報告書　課題番号26860363\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860363/26860363seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054761","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60621159"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60621159","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860363/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860363/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860363/26860363seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860363/26860363seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-05"}],"displaytype":"detail","filename":"ME-PR-KATAGIRI-T-kaken 2017-5p.pdf","filesize":[{"value":"95.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KATAGIRI-T-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48439/files/ME-PR-KATAGIRI-T-kaken 2017-5p.pdf"},"version_id":"25434495-a968-4eeb-825f-e18f3e4b6bf4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"発作性夜間血色素尿症(PNH)形質を利用したヒト造血幹細胞動態の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"発作性夜間血色素尿症(PNH)形質を利用したヒト造血幹細胞動態の解明"},{"subitem_title":"Analysis of human haematopietic stem cell movement with PNH-type cell","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-05"},"publish_date":"2019-07-05","publish_status":"0","recid":"48439","relation_version_is_last":true,"title":["発作性夜間血色素尿症(PNH)形質を利用したヒト造血幹細胞動態の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:13:18.939809+00:00"}