{"created":"2023-07-27T06:53:38.586812+00:00","id":48440,"links":{},"metadata":{"_buckets":{"deposit":"ca1d2b25-ede5-4540-a19c-10b06739691e"},"_deposit":{"created_by":18,"id":"48440","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48440"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048440","sets":["2812:2813:2820"]},"author_link":["2263","86266"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"6pLOHの割合は、造血の分化段階で異なり、末梢血中の白血球と同等の6pLOHを示すMEP, GMPと比較して、それらの前駆細胞であるCMPにおいては6pLOHの割合が明らかに低下していた。\nまた、マイクロアレイ解析の結果、CMPにおけるHLA欠失分画では、増殖を促進するCXCL12の発現が正常分画と比較して約30倍低下しており、このCXCL12のレセプターであるCXCR4の発現も、HLA欠失側で低下していた。その結果、セルサイクルが促進されず、CMPにおいてはHLA欠失分画の割合が著しく低下していることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"The percentage of 6pLOH was different among hematopoiesis stages in human bone marrow, and the progenitor cells showed much lower percentage of 6pLOH than that of MEP and GMP.\nI found approximately 30 times lower expression of CXCL12 which promotes the cell growth and proliferation cytokine than that of normal fraction with microarray analysis. As a result, I demonstrated the percentage of HLA deficient was significantly decreased, since the cell cycle was not promoted in the 6pLOH of CMP fraction with low CXCL12 and CXCR4 expression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24790968, 研究期間(年度):2012-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「HLAアレル欠失現象を利用したヒト造血幹細胞制御分子の同定」研究成果報告書　課題番号24790968\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790968/24790968seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054762","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域保健学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60621159"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60621159","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790968/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790968/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790968/24790968seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790968/24790968seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-05"}],"displaytype":"detail","filename":"ME-PR-KATAGIRI-T-kaken 2014-5p.pdf","filesize":[{"value":"494.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KATAGIRI-T-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48440/files/ME-PR-KATAGIRI-T-kaken 2014-5p.pdf"},"version_id":"83a4d868-b065-4b5f-876c-cd603be9ca66"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"HLAアレル欠失現象を利用したヒト造血幹細胞制御分子の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HLAアレル欠失現象を利用したヒト造血幹細胞制御分子の同定"},{"subitem_title":"Identification of human hematopoietic stem cell regulators with HLA allele deficient cells behavior","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-05"},"publish_date":"2019-07-05","publish_status":"0","recid":"48440","relation_version_is_last":true,"title":["HLAアレル欠失現象を利用したヒト造血幹細胞制御分子の同定"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:10:55.147612+00:00"}