{"created":"2023-07-27T06:53:38.931468+00:00","id":48451,"links":{},"metadata":{"_buckets":{"deposit":"9fe1febf-6d41-4828-8fea-40fe06ceadad"},"_deposit":{"created_by":18,"id":"48451","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48451"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048451","sets":["2812:2813:2815"]},"author_link":["77792"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2017-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"解糖系あるいはTCA回路において産生される代謝中間体は、様々な経路において利用される。我々は、がん悪性進展過程において高頻度に不活性化されるがん抑制遺伝子RBに着目し、解糖系酵素PGAM1がRBの支配下にあることを見出している。本研究では、RB不活性化により起こる代謝変化に着目し、エピジェネティクスに与えるインパクトを解析した。その結果、RBはKDM5Aを介して、胃がんにおけるグローバルなメチル化を制御し、種々の解糖系酵素がその支配下にあることを明らかにした。加えて、RB依存的な細胞分化する系において、PGAMが細胞分化を制御することが見出した。 ","subitem_description_type":"Abstract"},{"subitem_description":"The metabolic intermediates produced in the glycolytic or TCA cycle are utilized in various pathways. We focused on the tumor suppressor gene RB, which is frequently inactivated in the malignant progression of cancer, and found that the expression of glycolytic enzyme PGAM1 is regulated by RB. In this study, we focused on the metabolic changes caused by RB inactivation and analyzed the impact given by the metabolic alteration on epigenetics. As a result, RB regulates global methylation in gastric cancer via KDM5A, and it is revealed that various glycolytic enzymes are controlled by the RB-KDM5A axis. In addition, we found that PGAM contributes RB dependent cell differentiation in myogenesis of C2C12 and adipogenesis of 3T3L1.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K14992, 研究期間(年度):2017-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「PGAMによるエピジェネティクスリモデリングを介したがん悪性化機構の解明」課題番号17K14992\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K14992/17K14992seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054773","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所 特任助教(Ⅰ種) 264-6751  234-4521 skohno@staff.kanazawa-u.ac.jp"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30625463"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30625463","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K14992/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K14992/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K14992/17K14992seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K14992/17K14992seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-24"}],"displaytype":"detail","filename":"CA-PR-KOHNO-S-kaken 2019-5p.pdf","filesize":[{"value":"169.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-KOHNO-S-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48451/files/CA-PR-KOHNO-S-kaken 2019-5p.pdf"},"version_id":"0ae15ec1-e0a3-4055-9994-6af5f3998fd9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"PGAMによるエピジェネティクスリモデリングを介したがん悪性化機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PGAMによるエピジェネティクスリモデリングを介したがん悪性化機構の解明"},{"subitem_title":"Tumor progression through epigenetics remodeling by RB-PGAM","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"48451","relation_version_is_last":true,"title":["PGAMによるエピジェネティクスリモデリングを介したがん悪性化機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:35:07.227165+00:00"}