{"created":"2023-07-27T06:53:39.066906+00:00","id":48455,"links":{},"metadata":{"_buckets":{"deposit":"09b3fe29-a525-4c00-9d21-290b77237829"},"_deposit":{"created_by":18,"id":"48455","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48455"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048455","sets":["2812:2813:2817"]},"author_link":["86288","29"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は、生体内のほぼすべての臓器に存在し、主に有機カチオン性化合物を認識して細胞内に取り込む膜輸送体solute carrier について、その生体内での役割を解明する目的で、遺伝子欠損マウスを作製した。メタボローム解析を行ったところ、絶食時の小腸組織において糖新生の変化を示唆するデータを得た。その詳細な分子機構は不明であるが、新たな血糖調節機構や糖尿病をはじめとする代謝性疾患の病態解明につながる可能性がある。そこで、本研究では糖代謝のどこにOCTN1が関与するかを解明するとともに、その生体内基質の探索を目的とした。","subitem_description_type":"Abstract"},{"subitem_description":"We have previously established gene knockout mice for the solute carrier membrane transporter which is expressed in ubiquitous organs and mainly accepts organic cations as substrates. Our previous metabolome analyses using both wild-type and knockout mice have suggested possible change in glucose metabolism in the body due to the gene knockout. Identification of the molecular mechanism may lead to clarifying the regulatory mechanism for glucose homeostasis and diabetics. Therefore, the aim of the present study is to clarify the role of thie transporter in glucose metabolism and to identify its endogenous substrates.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K15000, 研究期間(年度):2015-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「膜輸送体による食後過血糖抑制機構の解明と過血糖抑制に働く新規生体内基質の探索」研究成果報告書　課題番号15K15000\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15000/15K15000seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054777","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30251440"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30251440","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15000/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15000/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15000/15K15000seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15000/15K15000seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-05"}],"displaytype":"detail","filename":"PH-PR-KATO-Y-kaken 2017-4p.pdf","filesize":[{"value":"411.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-KATO-Y-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48455/files/PH-PR-KATO-Y-kaken 2017-4p.pdf"},"version_id":"59ac9c0e-feef-4fa8-8af9-33644fd975dd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膜輸送体による食後過血糖抑制機構の解明と過血糖抑制に働く新規生体内基質の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膜輸送体による食後過血糖抑制機構の解明と過血糖抑制に働く新規生体内基質の探索"},{"subitem_title":"Mechanism of postprandial hyperglycemia due to transporter gene knockout and identification of endogenous substrates","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-05"},"publish_date":"2019-07-05","publish_status":"0","recid":"48455","relation_version_is_last":true,"title":["膜輸送体による食後過血糖抑制機構の解明と過血糖抑制に働く新規生体内基質の探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:13:23.019202+00:00"}