{"created":"2023-07-27T06:53:39.135016+00:00","id":48456,"links":{},"metadata":{"_buckets":{"deposit":"0115c1cc-a3e1-4c3e-a163-ef4070328804"},"_deposit":{"created_by":18,"id":"48456","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48456"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048456","sets":["2812:2813:2815"]},"author_link":["86290","29"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞の中と外との間での物質のやり取りに働くタンパク質群に膜輸送体がある。本研究は腸や肝臓における炎症時に、その存在量が増加する膜輸送体OCTN1に焦点を当て、OCTN1の炎症時における役割や、輸送を担う生体内物質（生体内基質）の解明、さらには生体内基質解明の方法論の確立を目的とした。その結果、生体内物質を有機化学的にアミノ化した後に網羅的に定量することでOCTN1の生体内基質を解明する技術（構造選択的メタボロミクス）を確立するとともに、OCTN1が慢性腎臓病モデルマウス、さらには腎臓病患者においてその生体内基質の一つであるエルゴチオネインを取り込むことで障害に対する防御に働く可能性を示した。","subitem_description_type":"Abstract"},{"subitem_description":"Transporters are involved in influx and efflux of endogenous compounds through cellular plasma membranes. The present study focused on one of such transporters OCTN1. OCTN1 is a unique transporter since its expression is known to be up-regulated in inflammatory conditions in certain organs such as gut and liver. The aim of the present study is to understand pathophysiological roles of OCTN1, to clarify its endogenous substrates, and to establish methodology to identify endogenous substrates. In the present study we have constructed structure-selective metabolomics in which endogenous compounds are first concentrated using transporter function, and amino group in endogenous compounds are comprehensively derivatized, followed by quantification of the compounds using LC-TOFMS. Based on this technique, we identified endogenous substrate of OCTN1. In addition, we also clarified that OCTN1 and its endogenous substrate may play a protective role in chronic kidney disease mice and patients.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15H04664, 研究期間(年度):2015-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「膜輸送体メタボロームによる炎症性腸肝疾患バイオマーカーの探索と発症機構の解明」課題番号15H04664\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04664/15H04664seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054778","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30251440"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30251440","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04664/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04664/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04664/15H04664seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04664/15H04664seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-24"}],"displaytype":"detail","filename":"PH-PR-KATO-Y-kaken 2019-6p.pdf","filesize":[{"value":"648.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-KATO-Y-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48456/files/PH-PR-KATO-Y-kaken 2019-6p.pdf"},"version_id":"87907202-cbbc-4ede-9837-0b8786e7c85a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膜輸送体メタボロームによる炎症性腸肝疾患バイオマーカーの探索と発症機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膜輸送体メタボロームによる炎症性腸肝疾患バイオマーカーの探索と発症機構の解明"},{"subitem_title":"Investigation of disease biomarkers using metabolome analysis targeted to transporters","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"48456","relation_version_is_last":true,"title":["膜輸送体メタボロームによる炎症性腸肝疾患バイオマーカーの探索と発症機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:35:05.819104+00:00"}