{"created":"2023-07-27T06:53:39.270545+00:00","id":48459,"links":{},"metadata":{"_buckets":{"deposit":"117598df-564c-41c6-a25a-5fe979444a0e"},"_deposit":{"created_by":18,"id":"48459","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48459"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048459","sets":["2812:2813:2819"]},"author_link":["2715","86291"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2011-04-28 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アダルト哺乳類の中枢神経は一旦損傷を受けると不可逆的ダメージとなり、細胞はアポトーシスに陥り、やがて機能喪失に至る。ところが魚類中枢神経は、損傷後の軸索再生・修復が可能であり、機能も完全に回復する。ここでは、魚類視神経を実験的に損傷し、タンパク架橋酵素であるトランスグルタミネースファミリーの一つ、Factor XIII-A(FXIII-A)遺伝子の発現とその軸索再生への関与について検討した結果、FXIII-A が視神経損傷後いち早く視神経および網膜で活性化され、創傷治癒・視神経軸索再生に深く関与することがわかった。","subitem_description_type":"Abstract"},{"subitem_description":"Unlike mammals, fish retinal ganglion cells have the capacity to repair their axons even after optic nerve transection. In the process of fish optic nerve regeneration, a large number of genes have been described as regeneration-associated molecules. Using molecular cloning techniques, we identified some cDNA clones belonging to the transglutaminase (TG) family as upregulation genes, and one of those was Factor XIII A subunit (FXIII-A). FXIII-A is quickly activated after optic nerve lesion and deeply involved in wound healing and optic nerve regeneration.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23618006, 研究期間(年度):2011-04-28 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ゼブラフィッシュ視神経再構築におけるFactorXIIIAの関与とその作用機序」課題番号23618006\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23618006/23618006seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054781","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域保健学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20162258"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20162258","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23618006/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23618006/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23618006/23618006seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23618006/23618006seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-05"}],"displaytype":"detail","filename":"ME-PR-SUGITANI-K-kaken 2015-6p.pdf","filesize":[{"value":"748.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SUGITANI-K-kaken 2015-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48459/files/ME-PR-SUGITANI-K-kaken 2015-6p.pdf"},"version_id":"4807211b-6e07-4785-8e16-835308c8f5c6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ゼブラフィッシュ視神経再構築におけるFactorXIIIAの関与とその作用機序","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ゼブラフィッシュ視神経再構築におけるFactorXIIIAの関与とその作用機序"},{"subitem_title":"Involvement of FactorXIII-A in fish optic nerve regeneration","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-05"},"publish_date":"2019-07-05","publish_status":"0","recid":"48459","relation_version_is_last":true,"title":["ゼブラフィッシュ視神経再構築におけるFactorXIIIAの関与とその作用機序"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:41:48.158267+00:00"}