{"created":"2023-07-27T06:53:39.473410+00:00","id":48467,"links":{},"metadata":{"_buckets":{"deposit":"53a6760d-4d3b-4142-a15c-4760175d7ce9"},"_deposit":{"created_by":18,"id":"48467","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48467"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048467","sets":["2812:2813:2816"]},"author_link":["86302","86303"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脊椎動物において血中カルシウム濃度は、骨や鱗（硬骨魚類）をカルシウム貯蔵庫にして、血中カルシウム低下ホルモン（カルシトニンとスタニオカルシン）と血中カルシウム上昇ホルモン（副甲状腺ホルモンやカルシトリオール（活性型ビタミンD）により調節されている。我々は、硬骨や鱗のない円口類ヤツメウナギにおける血中カルシウム調節ホルモンの役割を検討した。まずカルシトニンと受容体を同定した。さらに淡水順応したヤツメウナギの希釈海水移行による血漿カルシトニン濃度上昇と、イオン調節に重要な鰓における受容体mRNAの発現上昇を認めた。またスタニオカルシンを新たに同定し、脊椎動物の祖先から存在することを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Vertebrates possess bones and scales as calcium reservoirs. Blood calcium levels are regulated by hypocalcemic hormones including calcitonin and stanniocalcin and hypercalcemic hormones comprising parathyroid hormone and calcitriol(1,25-dihydroxyvitamin D3). We investigated the role of hormones involved in the regulation of blood calcium levels in the Japanese lamprey, Lethenteron japonicum, which has no bones and scales. Calcitonin and its receptor were identified. In addition, transfer of lamprey from freshwater to 1/3 seawater results in an increase in plasma calcitonin concentration and expression of its receptor mRNA in the gill. We also newly identified stanniocalcin.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K07126, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「硬骨を持たない原始的脊椎動物ヤツメウナギにおける新規カルシウム代謝機構 の解明」課題番号15K07126\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K07126/15K07126seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学環日本海域環境研究センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054789","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40378568"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40378568","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K07126/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K07126/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K07126/15K07126seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K07126/15K07126seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-08"}],"displaytype":"detail","filename":"OC-PR-SEKIGUCHI-T-kaken 2018-6p.pdf","filesize":[{"value":"187.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"OC-PR-SEKIGUCHI-T-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48467/files/OC-PR-SEKIGUCHI-T-kaken 2018-6p.pdf"},"version_id":"da49c2b6-b3d1-4274-96b6-dc779bd072b8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"硬骨を持たない原始的脊椎動物ヤツメウナギにおける新規カルシウム代謝機構 の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"硬骨を持たない原始的脊椎動物ヤツメウナギにおける新規カルシウム代謝機構 の解明"},{"subitem_title":"Clarification of novel calcium regulatory system in primitive vertebrate, Japanese lamprey, Lethenteron japonicum","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-08"},"publish_date":"2019-07-08","publish_status":"0","recid":"48467","relation_version_is_last":true,"title":["硬骨を持たない原始的脊椎動物ヤツメウナギにおける新規カルシウム代謝機構 の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:46:37.768829+00:00"}