{"created":"2023-07-27T06:53:39.607347+00:00","id":48469,"links":{},"metadata":{"_buckets":{"deposit":"cdf5d56d-31a9-4d35-9946-e084711b70e6"},"_deposit":{"created_by":18,"id":"48469","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48469"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048469","sets":["2812:2813:2821"]},"author_link":["86302","86303"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脊椎動物に近縁なナメクジウオを用い脊椎動物Calcitonin (CT) family の多様化の起源を研究した。まずCT、CT受容体 (CTR)、受容体修飾蛋白(RAMP)を同定し、それぞれ脊椎動物と相同であることを確認した。さらにCTR とRAMP の細胞株発現系による解析の結果、CTペプチドのリガンド活性には、CTRとRAMPの共発現が必要であること、RAMPには、CTRを細胞膜に移行する活性があることを明らかにした。このことから、脊椎動物とナメクジウオの共通祖先において、CTペプチド、CTR、RAMPが既に存在していることを示した。","subitem_description_type":"Abstract"},{"subitem_description":"Calcitonin (CT) family shows high molecular and functional diversification in vertebrates. To elucidate the origin of CT family, CT peptide, CT receptor (CTR), and receptor activity-modifying protein (RAMP) were identified from an amphioxus, Branchiostoma floridae, which is close animal of vertebrates. Furthermore, analysis ofCTR and RAMP expressed in mammalian cell line demonstrated that co-expression of CTR and RAMP is required for ligand activity of CT peptide, and that RAMP is necessary for cell-surface translocation of CTR. These results let us conclusion that CT peptide, CTR, and RAMP have already existed in the common ancestor between vertebrates and amphioxus.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23770069, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ペプチド-受容体-受容体修飾蛋白の共進化機構解明: ナメクジウオカルシトニンの研究」課題番号23770069\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23770069/23770069seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054791","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学環日本海域環境研究センター"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40378568"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40378568","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23770069/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23770069/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23770069/23770069seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23770069/23770069seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-08"}],"displaytype":"detail","filename":"OC-PR-SEKIGUCHI-T-kaken 2013-4p.pdf","filesize":[{"value":"382.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"OC-PR-SEKIGUCHI-T-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48469/files/OC-PR-SEKIGUCHI-T-kaken 2013-4p.pdf"},"version_id":"954d6fe8-35db-4c2a-873f-942efa9679b9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ペプチド-受容体-受容体修飾蛋白の共進化機構解明: ナメクジウオカルシトニンの研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ペプチド-受容体-受容体修飾蛋白の共進化機構解明: ナメクジウオカルシトニンの研究"},{"subitem_title":"Study of calcitonin (CT) family in an amphioxus, Branchiostoma floridae: Coevolution among CT peptide, CT receptor, and receptor activity-modifying protein","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-08"},"publish_date":"2019-07-08","publish_status":"0","recid":"48469","relation_version_is_last":true,"title":["ペプチド-受容体-受容体修飾蛋白の共進化機構解明: ナメクジウオカルシトニンの研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:34:18.976541+00:00"}