{"created":"2023-07-27T06:53:39.674082+00:00","id":48470,"links":{},"metadata":{"_buckets":{"deposit":"07ac4e44-5c7e-4a71-802c-07ebb91d0589"},"_deposit":{"created_by":18,"id":"48470","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48470"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048470","sets":["2812:2813:2815"]},"author_link":["86307","2213"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"86307","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60242476","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60242476"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究の目的は、魚類における黒色素胞刺激ホルモン（MSH）の骨代謝に対する新規作用を骨モデルであるウロコを用いて解析することである。本研究では、再生ウロコを用いて、MSHの骨代謝に対する作用をin vivo及びin vitroで解析を行い、MSHが破骨細胞及び骨芽細胞を活性化することを証明した。また、カルシウム代謝に関与しているカルシトニンの分泌をMSHが促していることもわかった。さらに、円鱗から櫛鱗への分化機構を調べるために、次世代シークエンス解析を行った。その結果、骨代謝関連遺伝子の制御機構の一端を明らかにすることができた。 ","subitem_description_type":"Abstract"},{"subitem_description":"The purpose of this study is to analyze the novel action of melanocyte-stimulating hormone (MSH) on bone metabolism using fish scales as a bone model. In this study, we analyzed the effects of MSH on bone metabolism in vivo and in vitro using regenerating scales and demonstrated that MSH promotes osteoclastic and osteoblastic activity. In addition, we found that MSH promotes the secretion of calcitonin, which is involved in calcium metabolism. Furthermore, next-generation sequencing analyses were performed to investigate the differentiation mechanism from cycloid scales to ctenoid scales. As a result, it was possible to clarify one of the regulatory mechanisms of bone metabolism related genes in the formation of ctenoid scales.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K07871, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「黒色素胞刺激ホルモンの骨への新規作用: 再生能力が高い硬組織(ウロコ)を用いた解析」課題番号16K07871\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K07871/16K07871seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054792","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学環日本海域環境研究センター"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60242476"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60242476","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07871/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07871/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K07871/16K07871seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K07871/16K07871seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 信雄"}],"nameIdentifiers":[{"nameIdentifier":"2213","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60242476","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60242476"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-24"}],"displaytype":"detail","filename":"OC-PR-SUZUKI-N-kaken 2019-6p.pdf","filesize":[{"value":"152.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"OC-PR-SUZUKI-N-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48470/files/OC-PR-SUZUKI-N-kaken 2019-6p.pdf"},"version_id":"d347278b-c0da-490b-9015-1171a7ddd731"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"黒色素胞刺激ホルモンの骨への新規作用: 再生能力が高い硬組織(ウロコ)を用いた解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"黒色素胞刺激ホルモンの骨への新規作用: 再生能力が高い硬組織(ウロコ)を用いた解析"},{"subitem_title":"Novel action of melanocyte-stimulating hormone on bone: Analysis using fish scales with a high regeneration ability","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"48470","relation_version_is_last":true,"title":["黒色素胞刺激ホルモンの骨への新規作用: 再生能力が高い硬組織(ウロコ)を用いた解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:30:25.373648+00:00"}