{"created":"2023-07-27T06:53:41.600373+00:00","id":48522,"links":{},"metadata":{"_buckets":{"deposit":"5944ab19-7845-4efa-bffb-2d6ec78cfa7a"},"_deposit":{"created_by":18,"id":"48522","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48522"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048522","sets":["2812:2813:2817"]},"author_link":["27","86390"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞増殖因子受容体をダイマー化する人工リガンド技術は再生医療に応用可能であるとともに、従来にない生物活性をもつ人工リガンドを創成できる可能性が考えられる。本研究は、異なる受容体同士を人為的にダイマー化することで、ヘテロ受容体のシグナル活性化につながるかを検討した。ダイマー形成の評価系としてsplit luciferase系と原子間力顕微鏡による解析系を確立した。一方、MET受容体、RET受容体、IGF受容体についてヘテロダイマー形成を誘導したが、シグナル活性化は認められなかった。増殖因子受容体の新たな組合せを検討し、ヘテロ受容体活性化人工リガンド創成の可能性を検討することが必要と考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"Artificial ligands that induce the dimerization of growth factor receptors may be applicable to regenerative medicine, and generation of artificial ligands that have unique and novel biological activities may be possible. We here investigated signal activation by hetero-dimerization between different growth factor receptors. The split luciferase fusion protein system and observation of receptor molecules by atomic force microscopy were performed and determined to be appropriate for evaluation of growth factor receptor dimerization. Hetero-dimer formation between MET, RET, and IGF receptors was induced in cultured cells using FKBP/FRB fusion receptors, however, activation of these receptor and downstream signaling molecules were not seen. Combination of other growth factor receptors seemed to be required to further clarify possibility for generation of artificial ligands capable of inducing hetero-receptor dimerization and activation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K14473, 研究期間(年度):2015-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ヘテロ受容体カップリングのシグナル特性と人工リガンド創成の研究」研究成果報告書　課題番号15K14473\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K14473/15K14473seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構ナノ生命科学研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054844","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90201780"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90201780","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14473/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14473/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K14473/15K14473seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K14473/15K14473seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-08"}],"displaytype":"detail","filename":"CA-PR-MATSUMOTO-K-kaken 2017-5p.pdf","filesize":[{"value":"292.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-MATSUMOTO-K-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48522/files/CA-PR-MATSUMOTO-K-kaken 2017-5p.pdf"},"version_id":"f1d17a16-82ba-4b4d-a37b-f5560cacca63"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヘテロ受容体カップリングのシグナル特性と人工リガンド創成の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヘテロ受容体カップリングのシグナル特性と人工リガンド創成の研究"},{"subitem_title":"Signal characteristics of heatero-receptor coupling and generation of artificial ligand","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-08"},"publish_date":"2019-07-08","publish_status":"0","recid":"48522","relation_version_is_last":true,"title":["ヘテロ受容体カップリングのシグナル特性と人工リガンド創成の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:13:28.059149+00:00"}