{"created":"2023-07-27T06:53:42.669422+00:00","id":48541,"links":{},"metadata":{"_buckets":{"deposit":"4dccdda6-2883-466d-8b9c-cd30adf3f55b"},"_deposit":{"created_by":18,"id":"48541","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48541"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048541","sets":["2812:2813:2816"]},"author_link":["69","86411"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"神経伝達物質受容体、イオンチャネルに代表される疎水性膜タンパクは、自己免疫性精神神経疾患の標的抗原となることが知られている。その診断検出システムを開発するために血自己抗原膜タンパクを大腸菌に大量発現させた。今回、グルタミン酸受容体サブユニット2種 (GluN1-1, GRIA2)と神経型アセチルコリン受容体サブユニット (nAChR-alpha7)の大腸菌大量発現を達成した。ナノファイバーに組み込むための溶媒の検討を行い、ファイバー化に適した条件を模索している。","subitem_description_type":"Abstract"},{"subitem_description":"In autoimmune neuropsychiatric diseases, neurotransmitter receptors and ionic channels are known to be targeted by autoantibodies that destruct neural tissues. In an attempt to establish a detection systems for autoantibodies, we produced these proteins in Escherichia coli. Of several proteins tried, two subunits for the glutamate receptor, GluN1-1 and GRIA2, and a neuronal nicotinic acetylcholine receptor, nAchR-alpha7 were successfully produced in large amount. We are now trying to find out media to dissolve these recombinant proteins and optimal conditions to integrate them into nanofibers.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K15190, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「抗原固相化ナノファイバーの創製と新規自己抗体検出法開発への応用」課題番号15K15190\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15190/15K15190seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学子どものこころの発達研究センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054863","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00210633"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00210633","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15190/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15190/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15190/15K15190seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15190/15K15190seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-11"}],"displaytype":"detail","filename":"CH-PR-YOKOYAMA-S-kaken 2018-4p.pdf","filesize":[{"value":"235.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CH-PR-YOKOYAMA-S-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48541/files/CH-PR-YOKOYAMA-S-kaken 2018-4p.pdf"},"version_id":"e9ef5169-c889-4496-9cc0-2a6977bbc52c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抗原固相化ナノファイバーの創製と新規自己抗体検出法開発への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗原固相化ナノファイバーの創製と新規自己抗体検出法開発への応用"},{"subitem_title":"Generation of antigene-fixed nanifibers and its application to autoantibody detection","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-11"},"publish_date":"2019-07-11","publish_status":"0","recid":"48541","relation_version_is_last":true,"title":["抗原固相化ナノファイバーの創製と新規自己抗体検出法開発への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:46:36.270255+00:00"}