{"created":"2023-07-27T06:53:42.939485+00:00","id":48554,"links":{},"metadata":{"_buckets":{"deposit":"18641485-76f4-4a02-93aa-0b21c77d666c"},"_deposit":{"created_by":18,"id":"48554","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48554"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048554","sets":["2812:2813:2823"]},"author_link":["519","86423"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"mTOR阻害剤であるTemsirolimusは悪性胸膜中皮腫細胞株の増殖抑制効果を濃度依存性に示すことをIn Vitroで示した。特にp70s6kのリン酸化を阻害すること、またアポトーシスのマーカーとして知られるcleaved-caspase3の発現レベルを亢進させることを確認した。FACS 法により、MSTO211H以外の細胞株、H226,H290,and Y-MESO14ではアポトーシスの誘導が確認された。さらにTemsirolimusとCisplatinは相乗効果を示すこと、Temsirolimusは抗血管新生効果、特にVEGF発現抑制効果を示すことを明らかにした。Temsirolimusは抗腫瘍効果と、血管新生抑制効果の両面の作用を持つことが示された。","subitem_description_type":"Abstract"},{"subitem_description":"The results suggest the therapeutic efficacy of temsirolimus against MPM in vitro. And it is expected that temsirolimus inhibits MPM growth not only by anticancer effect but by antangiogenic effect in vivo.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「悪性胸膜中皮腫に対するmTORを標的とした分子標的治療の基礎的検討」課題番号21791316\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21791316/21791316seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054876","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10397185"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10397185","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791316/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791316/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21791316/21791316seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21791316/21791316seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-11"}],"displaytype":"detail","filename":"HO-PR-TAMURA-M-kaken 2011-4p.pdf","filesize":[{"value":"232.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAMURA-M-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48554/files/HO-PR-TAMURA-M-kaken 2011-4p.pdf"},"version_id":"1a87740e-3b43-4f1e-8ce6-31872f49992f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"悪性胸膜中皮腫に対するmTORを標的とした分子標的治療の基礎的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"悪性胸膜中皮腫に対するmTORを標的とした分子標的治療の基礎的検討"},{"subitem_title":"Tensirolimus, mTOR Inhibitor, Inhibits Progression of Malignant Pleural Mesothelioma in Vitro","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-11"},"publish_date":"2019-07-11","publish_status":"0","recid":"48554","relation_version_is_last":true,"title":["悪性胸膜中皮腫に対するmTORを標的とした分子標的治療の基礎的検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:21:25.602081+00:00"}